Multisensory neuromodulation to improve visual field loss after stroke
Official title: Neuromodulation Through Multisensory Stimulation for Visual Field Deficits in the Subacute Stage of Disease
Run by Istituto Auxologico Italiano · NCT07358832 · Data updated 2026-11-12
This will try combining audio-visual training with noninvasive brain stimulation (tDCS) to help people within three months of stroke who have homonymous hemianopsia improve their visual field and visual scanning.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 48 (estimated) |
| Sponsor | Istituto Auxologico Italiano Academic / other |
| Locations | 1 site (Milan, Lombardy) |
| Status | Recruiting |
| Started | February 1, 2026 |
| Main results expected | February 28, 2028 |
| Study ends | January 31, 2029 |
| Registry record updated | January 22, 2026 |
| Trial ID | NCT07358832 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people within three months of an acquired brain injury with neuro‑ophthalmologically confirmed homonymous hemianopsia who do not have hemispatial neglect, conjugate eye‑movement disorders, other major neurological disease, or contraindications to tDCS (for example, epilepsy, implanted metallic/electronic devices, or pregnancy).
✕Probably not a fit
Patients with hemispatial neglect, disorders of conjugate eye movements, dementia or other major neurological disorders, chronic visual field loss beyond the subacute window, or contraindications to brain stimulation are unlikely to be eligible or to benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The protocol enrolls people in the subacute stage (within 3 months) after an acquired brain injury who have homonymous visual field defects. Participants receive audio-visual training—eye movement exercises paired with synchronized visual and auditory cues—while low‑intensity transcranial direct current stimulation (tDCS) is applied to the lesioned visual cortex to promote plasticity. The approach aims to speed and stabilize functional gains in scanning and daily tasks and potentially restore portions of the lost visual field, addressing a window earlier than most prior work. The study excludes participants with hemispatial neglect, disorders of conjugate eye movements, other major neurological disease, or contraindications to brain stimulation and is conducted at Istituto Auxologico Italiano in Milan.
Why it matters
Potential benefit: If successful, the combined AVT plus tDCS approach could speed recovery and expand visual fields after stroke, improving reading, navigation, independence, and mood.
How similar studies have gone: Early studies, mostly in chronic patients, suggest that pairing tDCS with audio‑visual training can speed and stabilize improvements, but evidence in the subacute stage is limited and still emerging.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Presence of subacute acquired brain injury (\< 3 months) with HVFD according to Neurophthalmological evaluation Exclusion Criteria: * Presence of hemispatial neglect (indexed by pathological asymmetries on paper-and-pencil tests) * Disorders of conjugated eye movements * Other neurological disorders (e.g., dementia) * Exclusion criteria for brain stimulation (i.e., epilepsy or family history of epilepsy; implanted electrodes, stimulators, pacemakers, infusion pumps, or any implanted metal device; pregnancy)
Where it's running
-
Istituto Auxologico Italiano IRCCS
Milan, Lombardy, Italy Recruiting
Study contacts
- Study coordinator: Nadia Bolognini, PhD
- Email: n.bolognini@auxologico.it
- Phone: 02619116127
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Deep phenotyping to explore recovery in young adults after stroke
This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.
-
Stem cell therapy for chronic stroke recovery
This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.
-
AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals
This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.
-
Web-based therapy using action observation and mirror therapy for arm weakness after stroke
This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.
-
Remote Ischaemic Conditioning for Fatigue After Stroke 2
Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.
-
Dual-task balance training plus computer-based cognitive training after stroke
In adults who recently had a stroke, the study tests whether adding computerized cognitive exercises to balance training improves balance and other recovery outcomes.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.