Multiprofen-CC cream to reduce hand osteoarthritis pain
Multiprofen-CC to Reduce Pain in Hand Arthritis (MRP-HAND): A Crossover Randomized Controlled Trial
PHASE3 · St. Joseph's Healthcare Hamilton · NCT06966206
This trial will try Multiprofen-CC cream to see if applying it to the hands reduces pain in adults with hand osteoarthritis compared with a placebo.
Quick facts
| Phase | PHASE3 |
|---|---|
| Study type | Interventional |
| Enrollment | 42 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | St. Joseph's Healthcare Hamilton (other) |
| Locations | 1 site (Hamilton, Ontario) |
| Trial ID | NCT06966206 on ClinicalTrials.gov |
What this trial studies
This randomized, crossover Phase 3 trial has participants apply Multiprofen-CC and a matching placebo cream in random order while continuing standard care, with dosing of 1 gram applied to the hands three times daily during treatment periods. Participants attend visits before starting, after two weeks, and at six weeks, and report symptoms throughout the study. Primary outcomes include changes in hand pain, with secondary measures of hand function, opioid use, patient global impression of change, and monitoring of side effects. The trial is conducted at St. Joseph's Healthcare Hamilton and enrolls adults meeting American College of Rheumatology criteria for hand osteoarthritis.
Who should consider this trial
Good fit: Adults aged 18 or older with hand osteoarthritis by ACR criteria who have pain or loss of hand function that interferes with daily life and can give informed consent and follow the protocol.
Not a fit: People with inflammatory arthritis (like rheumatoid arthritis), active hand skin wounds or conditions, known allergy to the cream, recent or planned hand surgery, significant liver or kidney impairment, pregnancy or breastfeeding, or daily opioid use for other chronic pain are unlikely to benefit or are excluded.
Why it matters
Potential benefit: If successful, this topical treatment could reduce hand pain and improve function while lowering reliance on oral pain medicines and their systemic side effects.
How similar studies have performed: Topical nonsteroidal anti-inflammatory formulations have shown pain relief in some osteoarthritis studies, but this specific Multiprofen-CC formulation for hand OA has limited direct trial evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (18+) * Have been diagnosed with hand osteoarthritis according to American College of Rheumatology criteria * Experience pain and/or loss of function in one or both hands that interferes with daily life * Provide informed consent Exclusion Criteria: * Unable to consent * Unable or unwilling to follow study protocol * Known allergy or contraindication to any of the study drugs or their ingredients * Have open wounds/cuts and/or skin conditions on the hand area * Pregnant or breastfeeding * History of impaired kidney or liver function * Rheumatoid or other inflammatory arthropathy * Hand surgery within the past 6 months or planned within the study period. * Use daily opioids (other than short acting codeine) for a chronic pain condition other than hand arthritis
Where this trial is running
Hamilton, Ontario
- St. Joseph's Healthcare Hamilton — Hamilton, Ontario, Canada (RECRUITING)
Study contacts
- Principal investigator: Carolyn Levis, MD, MSc, FRCS(C) — McMaster University
- Study coordinator: Breanne Flood, MSc
- Email: bflood@stjoes.ca
- Phone: 905-870-1382
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Hand Osteoarthritis, hand osteoarthritis, osteoarthritis, arthritis, topical, multiprofen