Multiplanar, high-frequency brain stimulation with personalized targeting

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will use structural MRI to tailor electrode placement for each participant and apply transcranial electrical stimulation with temporal interference (TES-TI) during three afternoon sessions. Each session includes four stimulation conditions in a randomized order, with 3 minutes before, 3 minutes during, and 3 minutes after stimulation while EEG records brain activity. The study uses a within-subject, single-blind, randomized, counterbalanced crossover design in up to 24 healthy adults, with sessions spaced at least one week apart. Primary goals are to determine if active TES-TI produces envelope-driven EEG effects compared with sham and various controls, and to explore how different amplitudes and frequencies influence the response.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Medically healthy (based on self-report and study team review)
* U.S. citizen or holding permanent resident status
* English-speaking (able to provide consent and complete questionnaires)

Exclusion Criteria:

* Current or past history of clinically significant neurological disorder or acquired neurological disease (e.g., stroke, traumatic brain injury), including intracranial lesions (including clinically significant findings identified on the structural MRI)
* History of inpatient psychiatric hospitalization
* History of head trauma resulting in prolonged loss of consciousness; or a history of \>3 grade I concussions
* Current poorly controlled headaches, including intractable or frequent migraines
* Any systemic illness or unstable medical condition that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.)
* History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG, or family history of treatment resistant epilepsy except for a single seizure of benign etiology (e.g. febrile seizures) in the judgment of a board-certified neurologist
* Possible pregnancy or plan to become pregnant in the next 6 months (self reported)
* Any metal in the head or body
* Any medical devices or implants (i.e. cardiac pacemaker, medication infusion pump, cochlear implant, vagal nerve stimulator)
* Dental implants
* Permanent retainers
* Any hair braid, dreadlocks, hair pieces, or extensions which cannot be taken out before the study sessions
* Any head coverings or headdress that participant feels uncomfortable removing for the purposes of study sessions
* Current use of medications known to substantially lower seizure threshold, specifically chlorpromazine, clozapine, bupropion, clomipramine, or maprotiline; or other medications at doses known to substantially lower seizure threshold in the judgment of the PI
* Active scalp lesions, broken skin, or skin conditions at planned electrode sites that would preclude safe electrode application
* Claustrophobia (a fear of small or closed places)
* Back problems that would prevent lying flat for up to two hours

Where it's running

• University of Wisconsin - Madison
  Madison, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Larissa Albantakis, PhD — UW School of Medicine and Public Health
• Study coordinator: MINT Study Team
• Email: mint@psychiatry.wisc.edu
• Phone: 608-263-4313

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.