Decision-support tool to aid blood biomarker testing discussions in primary care
Official title: Pilot Evaluation of a Tool to Support Communication About Blood Biomarker Testing for Cognitive Complaints in Primary Care
Run by University of Wisconsin, Madison · NCT07812337 · Data updated 2026-11-12
A brief tool is being tested to help primary care doctors talk with patients about blood biomarker testing for Alzheimer's disease and support shared decision-making.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years and up |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | University of Wisconsin, Madison Academic / other |
| Locations | 1 site (Madison, Wisconsin) |
| Status | Recruiting |
| Started | October 7, 2026 |
| Main results expected | November 15, 2027 |
| Study ends | November 15, 2027 |
| Registry record updated | October 28, 2026 |
| Trial ID | NCT07812337 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal participants are PCPs with experience or interest in cognitive diagnosis and community-dwelling adults aged 50 or older who participate in Simulation 2.
✕Probably not a fit
Patients who are not English-speaking, under 50, have cognitive impairment, or are not living independently may not benefit from this tool.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This pilot study evaluates a decision-support tool designed for primary care providers to facilitate conversations about blood biomarker testing for Alzheimer's disease. It uses two high-fidelity simulations to assess usability and the impact on shared decision-making. Simulation 1 measures acceptability and usability among PCPs (N=15). Simulation 2 compares SDM outcomes in encounters with versus without the tool (N=25 per arm). Feasibility of recruitment and processes for a future larger trial are also explored.
Why it matters
Potential benefit: If successful, the tool could make conversations about biomarker testing clearer and more collaborative for patients and their PCPs.
How similar studies have gone: Early work in decision-support tools suggests potential improvements in SDM, but this specific tool and setting are exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Simulation 1 and Simulation 2: PCPs with experience and interest in cognitive diagnosis. * Simulation 2: community dwelling older adults age 50 or older are eligible. Exclusion Criteria (PCP): none Participant Exclusion Criteria: * Not fluent in English * age \<50 years * pre-existing diagnosis of cognitive impairment * having an activated medical decision-make r or not living independently in the community. There will be no exclusion based upon sex/gender, race, or ethnicity.
Where it's running
-
School of Medicine and Public Health, University of Wisconsin
Madison, Wisconsin, United States Recruiting
Study contacts
- Principal investigator: Fred Ketchum, M.D., Ph.D. — University of Wisconsin, Madison
- Study coordinator: Fred Ketchum, M.D., Ph.D.
- Email: BiomarkersInPrimarycare@neurology.wisc.edu
- Phone: 608-265-5523
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Using a blood test to detect Alzheimer's in hospitalized older adults with sudden confusion
This will test whether the Quest AD-Detect blood test can identify underlying Alzheimer's disease in hospitalized patients aged 60–90 who have new confusion, delirium, or encephalopathy.
-
Improving math skills in children with learning disabilities
This study tests a new way to help children with learning disabilities improve their math skills by using different methods to see what works best for them.
-
18F-FES PET/MRI to find hidden disease in invasive lobular breast cancer
This study tests whether adding 18F-FES PET/MRI can reveal more disease in lobular breast cancer than standard imaging alone.
-
Share or Not to Share: A Peer-Led Support Program for Caregivers of Autistic Young Adults
A group, peer-led program tests how six virtual sessions can support family caregivers of autistic young adults (ages 18–26) in navigating roles, sharing experiences, and planning for the future.
-
Durvalumab plus histotripsy for intrahepatic cholangiocarcinoma
This study tests whether adding histotripsy to ongoing durvalumab helps people with advanced intrahepatic cholangiocarcinoma by boosting the immune response and checking safety.
-
Proton Therapy Treatment-Planning Software: Checking How Well RayStation and RayCare Work in Real Care
This study tests whether the RayStation 2025 and RayCare 2025 software upgrades reliably support delivering standard proton therapy to adults.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.