Multimodal exercise program for people with multiple sclerosis
Official title: Effect of Multimodal Exercise Training on Disease Activity and Functional Status in Patients With Multiple Sclerosis
Run by Istanbul University - Cerrahpasa · NCT06676618 · Data updated 2026-11-12
This trial will test whether a combined in-person and video-based exercise program can help people with multiple sclerosis improve disability, fitness, balance, fatigue, quality of life, and disease activity.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 65 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Istanbul University - Cerrahpasa Academic / other |
| Locations | 2 sites (Istanbul, Buyukcekmece and 1 other locations) |
| Status | Recruiting |
| Started | February 10, 2025 |
| Main results expected | May 1, 2027 |
| Study ends | May 1, 2028 |
| Registry record updated | March 17, 2026 |
| Trial ID | NCT06676618 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ambulatory adults diagnosed with multiple sclerosis who have EDSS scores between 3.0 and 5.5, are literate, have internet access, have not had a relapse or corticosteroid treatment within the past 3 months, and have not participated in a standardized rehab program in the prior 3 months.
✕Probably not a fit
People who are non-ambulatory, have EDSS outside 3.0–5.5, recent relapse or steroid treatment, pregnancy, significant orthopedic/visual/psychiatric/cognitive problems, active infections or cancer, or no internet access are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
People with multiple sclerosis who are ambulatory (EDSS 3.0–5.5) will be randomly assigned to a 12-week multimodal exercise program or to a control group with no exercise during the study period. The intervention includes three exercise sessions per week (one supervised in person and two delivered asynchronously via video telerehabilitation) combining aerobic, strengthening, and balance training. Outcomes include disease activity, disability level, aerobic capacity, physical activity, balance, fatigue, and quality of life, with neuroimaging used to capture changes in brain function. The study aims to compare the functional and disease-related effects of blended face-to-face and telerehabilitation exercise versus no exercise.
Why it matters
Potential benefit: If successful, the program could improve physical function, reduce symptoms such as fatigue, and enhance quality of life for people with MS while offering a hybrid care option.
How similar studies have gone: Previous trials have shown that exercise and telerehabilitation can improve symptoms and adherence and may match in-person therapy for functional outcomes, but effects on MS disease activity remain unclear.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Being diagnosed with multiple sclerosis by a neurologist * Volunteering to participate in the study * Being ambulatory * EDSS between 3.0-5.5 * Being literate * Having internet access * Not having participated in a standardized physiotherapy and rehabilitation program in the last 3 months Exclusion Criteria: * Having an orthopedic problem affecting its mobility * Having psychiatric problems, severe cognitive impairment, or epilepsy in addition to the MS diagnosis * Blurred vision or visual impairment * Pregnancy * Having had an attack or received corticosteroid treatment 3 months before participating in the study * Having a disease affecting immunological parameters (infection, cancer, etc.)
Where it's running
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Istanbul University-Cerrahpasa
Istanbul, Istanbul, Turkey (Türkiye) Recruiting -
Istanbul University-Cerrahpasa
Istanbul, Buyukcekmece, Turkey (Türkiye) Not yet recruiting
Study contacts
- Principal investigator: Pelin Vural, MSc — Istanbul University-Cerrahpasa Institute of Postgraduate Education
- Study coordinator: Pelin Vural, MSc
- Email: pelinvural7@gmail.com
- Phone: +905344245350
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.