Multicomponent Exercise to Prevent Disability During Hospitalization
Official title: Prevention of Disability in Older Adults: From the Patient to the Molecule - A Randomized Controlled Trial (RCT)
Run by Fundacion Miguel Servet · NCT07707310 · Data updated 2026-11-12
This trial tests whether a multicomponent exercise program helps prevent disability in adults aged 75 and older while they are in the hospital for acute medical conditions.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 75 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Fundacion Miguel Servet Academic / other |
| Locations | 1 site (Pamplona) |
| Status | Recruiting |
| Started | February 1, 2025 |
| Main results expected | November 1, 2027 |
| Study ends | December 1, 2027 |
| Registry record updated | July 16, 2026 |
| Trial ID | NCT07707310 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Hospitalized patients aged 75 or older admitted for acute medical conditions who can participate in a multicomponent exercise program and provide informed consent.
✕Probably not a fit
Patients with terminal illness, severe neurocognitive impairment, substantial baseline disability, inability to follow up, or medical contraindications to exercise may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this randomized study conducted at a tertiary Spanish hospital, participants 75 years and older admitted to an acute care unit are assigned to a multicomponent exercise program or usual care. The program focuses on strength, balance, and aerobic training and is delivered during hospitalization with follow-up assessments at discharge, 1 month, and 3 months post-discharge. Researchers will analyze subgroups to see who benefits most, examine sociodemographic and clinical factors linked to response, and explore biomarkers related to inflammation and aging. Key eligibility criteria include age, ability to participate in exercise, and absence of terminal illness or severe cognitive/functional impairment. The trial aims to determine if the intervention can reduce hospitalization-associated disability and improve functional and cognitive outcomes.
Why it matters
Potential benefit: If successful, patients may maintain or improve independence in daily activities after hospitalization and recover functional and cognitive capacity more quickly.
How similar studies have gone: Previous work in geriatric inpatient care supports exercise-based approaches to reduce disability, though this exact multicomponent protocol with biomarker integration is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age equal to or greater than 75 years, admitted to the acute care unit for medical conditions. Exclusion Criteria: * Explicit refusal expressed verbally or refusal to sign the informed consent by the patient/main caregiver/legal guardian or inability to obtain it. * Life expectancy of less than 3 months or terminal oncological or non -oncological disease. * Inability to follow up. * Inability to participate in a multicomponent exercise program. * Medical contraindication to exercise. * Major neurocognitive disorder at moderate to severe stage (GDS - Fast Reisberg 5-7). * Moderate to severe disability (measured by the Barthel Index (BI \<60)). Expected hospital stay of less than 6 days.
Where it's running
-
Hospital Universitario de Navarra
Pamplona, Spain Recruiting
Study contacts
- Principal investigator: Nicolas Martinez-Velilla — Navarrabiomed-Fundación Miguel Servet-Hospital de Navarra
- Study coordinator: Nicolas Martinez-Velilla
- Email: nicolas.martinez.velilla@navarra.es
- Phone: +34 848422287
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.