Beetroot Extract and Exercise for Health in Adults Aged 75+
Official title: Assessment of the Benefits of Beetroot Extract for Improving the Quality of Life of Older People: a Randomised Clinical Trial.
Run by Fundacion Miguel Servet · NCT07666685 · Data updated 2026-11-12
This study tests whether beetroot extract, alone and with a multicomponent exercise program, can improve blood pressure, functional performance, and cognitive function in adults 75 and older.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 75 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Fundacion Miguel Servet Academic / other |
| Locations | 1 site (Pamplona, Navarre) |
| Status | Recruiting |
| Started | March 24, 2026 |
| Main results expected | October 2027 |
| Study ends | November 2027 |
| Registry record updated | June 30, 2026 |
| Trial ID | NCT07666685 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 75 years and older who can ambulate independently, communicate effectively, tolerate exercise, and have a Barthel Index above 60.
✕Probably not a fit
Patients with advanced dementia, unstable medical conditions, ischemic heart disease, heart failure, severe kidney impairment, or hypotension may not benefit and could be excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial explores the effects of beetroot extract (high in dietary nitrate) on cardiovascular, functional, and cognitive outcomes in very old adults. Participants will be assigned to beetroot extract, a placebo, or both beetroot extract and a structured physical exercise program. The study aims to determine whether the supplement, exercise, or their combination can improve vascular health, daily function, and cognitive performance. The trial targets community-daling older adults recruited from a geriatrics service and primary care settings. Results could inform low-cost strategies to support healthy aging in this population.
Why it matters
Potential benefit: If successful, beetroot extract with or without exercise could help lower blood pressure and support better physical and cognitive function in very old adults.
How similar studies have gone: Other studies have shown benefits of nitrate-rich beetroot preparations and exercise on vascular health, but data in very old adults are limited and the combined effects are less established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Adults aged 75 years and older recruited from the Geriatrics Service of the Hospital Universitario de Navarra (HUN) or primary care settings. 2. Ability to ambulate independently. 3. Ability to communicate effectively. 4. Ability to tolerate physical exercise. 5. Barthel Index score greater than 60 points. Exclusion Criteria: 1. Refusal or inability of the participant, caregiver, or legal guardian to provide written informed consent. 2. Advanced or severe dementia (Global Deterioration Scale \[GDS\] stages 6-7). 3. Unstable medical condition or terminal illness with a life expectancy of less than 6 months. 4. Ischemic heart disease or congestive heart failure. 5. Severe renal insufficiency. 6. Hypotension.
Where it's running
-
Hospital Universitario de Navarra
Pamplona, Navarre, Spain Recruiting
Study contacts
- Principal investigator: Nicolas Martinez-Velilla, MD-PhD — Navarrabiomed-Fundación Miguel Servet-Hospital Universitario de Navarra
- Study coordinator: Nicolas Martinez-Velilla, Md-PhD
- Email: nicolas.martinez.velilla@navarrra.es
- Phone: 00 34 848422222
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.