MRI Analysis of Growth in Intracranial Aneurysms
Official title: 4D-MRI Morphological Study of Local Growth in Cerebral Aneurysms
Run by CHU de Reims · NCT06705452 · Data updated 2026-11-12
This study tests whether additional 4D Flow MRI can help detect aneurysm growth and identify biomarkers to predict rupture risk in adults with unruptured intracranial aneurysms.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 281 (estimated) |
| Sponsor | CHU de Reims Academic / other |
| Locations | 1 site (Reims) |
| Status | Recruiting |
| Started | July 8, 2026 |
| Main results expected | February 7, 2032 |
| Study ends | July 8, 2032 |
| Registry record updated | August 7, 2026 |
| Trial ID | NCT06705452 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with one or more unruptured intracranial aneurysms, under follow-up at the participating center, who consent to participate and are enrolled in the national health insurance program.
✕Probably not a fit
Patients whose aneurysms do not show growth or who do not exhibit relevant imaging biomarkers may not receive additional benefit from the imaging approach studied.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study uses additional 4D Flow MRI sequences to explore whether imaging biomarkers and hemodynamics relate to aneurysm growth. It enrolls adults with one or more unruptured intracranial aneurysms followed at a participating center. The goal is to see if MRI-based measures can help predict which aneurysms are more likely to enlarge and potentially rupture, guiding treatment decisions. Participants already in the national healthcare program may join, provided they meet eligibility and consent procedures. The study focuses on non-invasive imaging to improve risk stratification for management of cerebral aneurysms.
Why it matters
Potential benefit: If successful, participants and future patients could benefit from improved prediction of aneurysm growth and rupture risk, potentially informing earlier or tailored interventions.
How similar studies have gone: Prior research has shown that imaging and hemodynamic assessments can relate to aneurysm behavior, but the added value of 4D Flow MRI for predicting growth is being investigated and remains exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
inclusion criteria: * Patients with one or more unruptured intracranial aneurysms followed up at the participating center. Patients may have other ruptured and/or treated aneurysms * Patient older than 18 years * Patient consenting to participate to the study * Patient enrolled in the national healthcare insurance program exclusion criteria: * Patients who have already received surgical or endovascular treatment for all their aneurysm(s), or who are due to receive such treatment in less than 2 months. * Patients with only ruptured aneurysm(s) * Patients with arteriovenous malformations (treated or untreated) * Patients with a contraindication to MRI * Patients with an allergy to one of the contrast agents (Iodixanol, Gadoteric acid) * Pregnant or breast-feeding patients * Patients protected by law.
Where it's running
-
Damien JOLLY
Reims, France Recruiting
Study contacts
- Study coordinator: Sébastien SOIZE
- Email: ssoize@chu-reims.fr
- Phone: 03 10 73 62 17
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.