Comparing protein patterns in extracellular vesicles from different blood vessels in people with ruptured or unruptured brain aneurysms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will collect blood during neurointerventional procedures from the femoral vein, internal jugular vein, and internal carotid artery of adults with ruptured or unruptured intracranial aneurysms. Extracellular vesicles will be isolated from those samples and analyzed with proteomic methods to map protein differences across vascular locations and between hemorrhagic and non-hemorrhagic cases. The study focuses on patients aged 18–60 who are undergoing treatment under general anesthesia, with ruptured cases sampled within three days of symptom onset. As an observational project, there is no treatment intervention; findings aim to identify candidate EV-derived protein biomarkers linked to diagnosis and prognosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\. Aged between 18 and 60 years, regardless of gender; 2. Diagnosed with intracranial aneurysm confirmed by MRA, CTA, or DSA; 3. Patients with aneurysmal subarachnoid hemorrhage must have CT imaging evidence of hemorrhage, and blood collection must occur within 3 days of symptom onset; 4. Scheduled to undergo neurointerventional surgery for intracranial aneurysm under general anesthesia, with the procedure starting between 8:00 AM and 12:00 PM; 5. Willing to comply with the study protocol and data collection procedures; 6. Able to understand and sign the informed consent form.

Exclusion Criteria:

* 1\. Patients with a pre-onset (in hemorrhagic cases) or preoperative (in non-hemorrhagic cases) Modified Rankin Scale (MRS) score ≥ 2; 2. Presence of other neurological disorders such as Parkinson's disease, Alzheimer's disease, cerebral infarction, brain tumors, epilepsy, etc.; 3. Presence of other systemic diseases such as diabetes, coronary artery disease, cancer, infections, hematological diseases, or severe metabolic disorders that may significantly affect the evaluation of blood EVs; 4. History of severe hepatic or renal dysfunction (ALT \> 3 times the upper limit of normal; creatinine \> 225 μmol/L); 5. Patients who cannot tolerate anesthesia, anticoagulant therapy, or who have coagulation disorders; 6. History of severe allergic reactions to contrast agents; 7. Pregnant women; 8. Patients participating in other clinical trials who have not yet completed follow-up.

Where it's running

• First Hospital of Jilin University
  Changchun, Jilin, China Recruiting

Study contacts

• Study coordinator: Zheng Wan, Medical Doctor， MD
• Email: wanzheng@jlu.edu.cn
• Phone: 86-18743059601

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.