Morphine injection near the stellate ganglion to reduce heart damage after a heart attack

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with acute STEMI planned for PCI within 24 hours are randomized to receive a single ultrasound‑guided injection of 10 mg morphine or saline around the left stellate ganglion before coronary recanalization. Investigators will monitor myocardial injury during the hospital stay, record symptoms and any injection‑related adverse events, and track clinical outcomes up to one year. Key exclusions include severe hemodynamic instability or mechanical complications of MI, prior MI or cardiomyopathy, coagulopathy or anticoagulant use that precludes injection, opioid allergy or addiction, pregnancy, and severe organ failure. The trial is conducted at two affiliated hospitals of Anhui Medical University in Hefei and uses placebo control and randomization to compare morphine infiltration versus saline.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Aged ≥18 years, Male or Female.
* Acute ST-segment elevation myocardial infarction (STEMI) patients planned for percutaneous coronary intervention (PCI). Acute STEMI is defined as: electrocardiogram shows ST-segment elevation ≥0.2 mV in two or more adjacent leads, or new left bundle branch block (LBBW).
* Within 24 hours of the onset of infarct-related chest pain.
* Obtaining informed consent from the patient and their family.

Exclusion Criteria:

* Patients with severe complications of myocardial infarction, such as uncontrollable acute left heart failure and pulmonary edema, severe cardiogenic shock after cardiopulmonary resuscitation, severe mechanical complications including ventricular septal defect, papillary muscle rupture, and rupture of the left ventricular free wall;
* Patients with old myocardial infarction, or cardiomyopathy, or malignant arrhythmias controlled by antiarrhythmic drugs;
* Patients with coagulation disorders due to systemic diseases and those who are currently using anticoagulants and are not suitable for injection;
* Patients allergic to opioids or with a history of opioid addiction and those participating in other clinical studies;
* Pregnant or breastfeeding women;
* Patients with severe organ dysfunction or failure, such as liver failure, renal failure, and respiratory failure;
* Patients with severe infections;
* Patients with severe mental illness that cannot cooperate and those taking antipsychotic drugs;
* Other patients considered unsuitable for this study by the researchers.

Where it's running

• The First Affiliated Hospital of Anhui Medical University
  Hefei, China Recruiting
• The Second Affiliated Hospital of Anhui Medical University
  Hefei, China Recruiting

Study contacts

• Study coordinator: Shiyun Jin
• Email: xingzheruyun@126.com
• Phone: +86 055163869480

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.