Morning versus evening flu vaccination for adults with chronic kidney failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Seasonal influenza vaccination is recommended for people with chronic renal insufficiency, but antibody responses are often weaker in this group. Recent research suggests the time of day of vaccination can influence immune responses. In this single-center interventional study at CHU Nice, eligible participants will receive the influenza vaccine either in the morning or in the evening and have blood samples taken to compare serological responses. The goal is to determine whether morning administration yields higher antibody levels than evening administration in this immunocompromised population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Chronic renal failure patient at stage 4 or 5 (i.e. estimated GFR \< 30mL/min/1.73m2); or Dialysis patient; or renal transplant patient regardless of GFR;
* Age ≥ 18 years;
* Indication for influenza vaccination;
* Express free and informed consent.

Exclusion Criteria:

* Known hypersensitivity to influenza vaccine or egg proteins;
* Previous influenza vaccination for the current season;
* Current infection;
* Current acute illness;
* Treatments with a major impact on vaccine response:
* Treatment of rejection within the previous 3 months;
* Renal transplantation with induction performed within the previous 6 months;
* Immunosuppressive treatment including CTLA4 agonist, complement inhibitor, anti-CD20;
* Treatments that may distort the serological response: Polyvalent immunoglobulin infusion within the preceding 3 months;
* Vulnerable persons (minors, adults under guardianship or trusteeship, persons deprived of their liberty, persons unable to speak French);
* Subjects not affiliated to Social Security.

Where it's running

• CHU Nice - Hôpital Pasteur 2
  Nice, Alpes-Maritimes, France Recruiting

Study contacts

• Principal investigator: GOSSET Clément, MD — Centre Hospitalier Universitaire de Nice
• Study coordinator: GOSSET Clément, MD
• Email: gosset.c@chu-nice.fr
• Phone: 492038632

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.