Monitoring depression symptoms during therapy using mobile technology

Intersession Processes in Psychotherapeutic Treatments Using an Ecological Momentary Assessment Approach (ISA-Bell)

Not applicable Interventional University of Zurich · NCT05553197

This study tests if using a smartphone to track depression symptoms during therapy can help people with mild to moderate depression feel better compared to regular therapy alone.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment84 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Zurich Academic / other
Locations1 site (Zurich, Canton of Zurich)
Trial IDNCT05553197 on ClinicalTrials.gov

What this trial studies

This trial investigates the effects of adding mobile monitoring of symptoms to traditional Cognitive Behavioral Therapy (CBT) for patients with mild to moderate depression. Participants will be randomly assigned to receive either CBT with Ecological Momentary Assessment (EMA) or standard CBT alone. The EMA involves answering symptom-related questions via smartphone twice daily during the therapy sessions. The study aims to determine if this monitoring can enhance treatment outcomes compared to standard therapy. A total of 84 patients will be involved in the trial.

Who should consider this trial

Good fit: Ideal candidates are adults diagnosed with mild to moderate depression who own a smartphone with internet access.

Not a fit: Patients with severe depression, acute suicidality, or other significant mental health disorders may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could lead to improved treatment outcomes for patients with depression by providing real-time monitoring and support.

How similar studies have performed: Other studies have shown promise in using mobile technology for monitoring mental health, but this specific approach is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* ICD-10 diagnosis of mild or moderate depression, first or recurrent episode (F32.0, F32.1, F33.0, F33.1)
* PHQ-9 ≥ 5
* Possession of smartphone with internet access
* Signed informed consent

Exclusion Criteria:

* Acute or past suicidality; self-reported
* Acute addiction (F10 - F19)
* Dysthymia (F34.1), postpartum depression, or severe depression (F32.3; F33.3)
* PHQ-9 \> 20
* Depression not main mental health concern
* Planned onset or planned change in antidepressant medication
* History of psychotic symptoms, bipolar disorder, personality disorders, or organic brain disorders
* Cognitive impairment or physical disability that would hinder psychotherapy or the use of a smartphone

Where this trial is running

Zurich, Canton of Zurich

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions DepressionPsychotherapyMonitoringRandomised Controlled Trial
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.