Monitoring brain blood flow during general anesthesia
Change in Brain Perfusion During Induction of General Anesthesia: Relationship Between Transcranial Doppler, Bispectral Index and Cerebral Oximetry : a Prospective Observational Study CERVO2
Assistance Publique - Hôpitaux de Paris · NCT04288869
This study is testing how to keep blood flow to the brain stable during general anesthesia in adults with heart risks to help improve their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 101 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris (other) |
| Locations | 1 site (Paris) |
| Trial ID | NCT04288869 on ClinicalTrials.gov |
What this trial studies
This study evaluates changes in cerebral perfusion in adult patients undergoing general anesthesia, particularly focusing on those with cardiovascular risk factors. Using a combination of transcranial Doppler (TCD), near-infrared spectroscopy (NIRS), and Bispectral Index (BIS) monitoring, the study aims to establish individualized blood pressure targets to maintain optimal cerebral perfusion. Measurements will be taken during anesthesia induction and in response to episodes of arterial hypotension. The goal is to improve patient outcomes by better understanding the relationship between blood pressure and cerebral perfusion.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are scheduled for interventional radiology procedures or orthopedic surgeries requiring general anesthesia.
Not a fit: Patients under 18, pregnant women, or those who oppose participation in the study will not benefit from this research.
Why it matters
Potential benefit: If successful, this study could lead to improved monitoring and management of cerebral perfusion during anesthesia, potentially reducing the risk of neurological complications.
How similar studies have performed: Previous studies have indicated the importance of monitoring cerebral perfusion during anesthesia, suggesting that this approach may yield valuable insights, although the specific combination of methods used here is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Major patients (≥ 18 years old) * Eligible for an interventional radiology procedure or orthopedic surgery under general anesthesia. * Patients who expressed their non-opposition to participation in this research Exclusion Criteria: * Patients under the age of 18. * Patient opposed to participation in the protocol * Pregnant woman * Patient under judicial protection measure * Patient without affiliation to a social security scheme-
Where this trial is running
Paris
- AP-HP, Lariboisière Hospital, Department of Anesthesiology and Intensive Care — Paris, France (RECRUITING)
Study contacts
- Principal investigator: Fabrice VALLEE, MD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Joaquim MATEO, MD
- Email: joaquim.mateo@aphp.fr
- Phone: +33 (0)1 49 95 83 74
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Interventional Radiology, Orthopedic Surgery, cerebral perfusion, general anesthesia, hypotension, transcranial Doppler, Bispectral Index, Near-infrared spectroscopy