Monitoring brain activity during mechanical ventilation
Impact of Mechanical Ventilation on Hippocampal Oscillation and Respiratory-hippocampus Coupling
Beijing Sanbo Brain Hospital · NCT06480162
This study is testing how mechanical ventilation affects brain activity in ICU patients, especially those with drug-resistant epilepsy, to see if we can prevent brain injury while they are being weaned off the ventilator.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Beijing Sanbo Brain Hospital (other) |
| Locations | 1 site (Beijing, Beijing Municipality) |
| Trial ID | NCT06480162 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the impact of mechanical ventilation on the hippocampus in ICU patients, particularly focusing on ventilator-associated brain injury (VABI). It aims to monitor hippocampal EEG activity while patients are weaned off mechanical ventilation, exploring the relationship between breathing patterns and hippocampal activity. Patients with drug-resistant epilepsy will have simultaneous intracranial EEG recordings and respiratory data collected during various mechanical ventilation scenarios. The study seeks to clarify the effects of mechanical ventilation on brain function and the potential for preventing VABI.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with drug-resistant epilepsy who are scheduled for stereoelectroencephalography.
Not a fit: Patients with recent seizures, structural brain damage, cognitive impairment, or those who have been mechanically ventilated for more than 24 hours may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and prevention of brain injuries associated with mechanical ventilation in critically ill patients.
How similar studies have performed: While there is substantial preclinical evidence regarding the effects of mechanical ventilation on the brain, this specific approach in human patients is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: ≥ 18 years * ASA: I - II * w/ electrode inside hippocampus (≥ 1 contacts) * Singed consent form Exclusion Criteria: * Seizure occurrence ≤ 36 hours before op. * Structural brain damage * History of using: opioids, enzyme-inducing medications, sleep aids, or excessive alcohol consumption * History of mechanical ventilation (\>24h) * Cognitive impairment * Operation within 6 months * Participate in other clinical trials in the last four weeks * Pregnant or breastfeeding
Where this trial is running
Beijing, Beijing Municipality
- Beijing Sanbo Brain Hospital, Capital Medical University — Beijing, Beijing Municipality, China (RECRUITING)
Study contacts
- Principal investigator: Zhonghua Shi, PhD,MD — Capital Medical University
- Study coordinator: Zhonghua Shi, PhD,MD
- Email: z.shi@mail.ccmu.edu.cn
- Phone: 010-62856764
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Mechanical Ventilation Complication, Brain Injuries, Ventilator Associated Brain Injury, Hippocampus Oscillation, Mechanical Ventilation