Monitoring brain activity and oxygen levels in ARDS patients in the ICU
Depth of Sedation and Its Impact on Cerebrovascular Reactivity in Acute Respiratory Distress Syndrome: a Pilot Analysis
This study is testing if new non-invasive methods can help doctors find the right level of sedation for patients with acute respiratory distress syndrome in the ICU by monitoring their brain activity and oxygen levels.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Manitoba Academic / other |
| Locations | 1 site (Winnipeg, Manitoba) |
| Trial ID | NCT05847634 on ClinicalTrials.gov |
What this trial studies
This study investigates the feasibility of using non-invasive monitoring techniques, specifically processed electroencephalography (EEG) and near-infrared spectroscopy (NIRS), to assess the optimal depth of sedation in patients with acute respiratory distress syndrome (ARDS) in the intensive care unit (ICU). The research aims to determine how these monitoring methods can help minimize the correlation between brain oxygenation and sedation levels. Data collected will include demographic information, medical history, and sedation dosages, allowing for a comprehensive analysis of sedation effects on cerebrovascular reactivity in ARDS patients.
Who should consider this trial
Good fit: Ideal candidates are adult patients admitted to the ICU with confirmed ARDS requiring deep sedation and/or neuromuscular blockade.
Not a fit: Patients who have been in the ICU for more than 24 hours or are deemed to have imminent death will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved sedation management in ARDS patients, enhancing their recovery and outcomes.
How similar studies have performed: While this approach is novel in the context of ARDS, similar monitoring techniques have shown promise in other critical care settings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patient admitted to the ICU * ARDS confirmed according to the Berlin Definition * Invasive mechanical ventilation * Deep sedation and/or neuromuscular blockade required for ARDS treatment at the discretion of the treating medical team * Application of monitoring devices feasible Exclusion Criteria: * More than 24 hours elapsed since ICU admission * Death is deemed imminent and inevitable during the next 24 hours * Known allergy to a textile component of the device * Consent declined from patient or authorized third party * The treating clinician believes that participation in the study would not be in the best interest of the patient
Where this trial is running
Winnipeg, Manitoba
- Health Sciences Centre Winnipeg — Winnipeg, Manitoba, Canada (Recruiting)
Study contacts
- Principal investigator: Asher Mendelson, MD PhD — University of Manitoba
- Study coordinator: Asher Mendelson, MD PhD
- Email: asher.mendelson@umanitoba.ca
- Phone: 204-787-8059
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.