Monitoring blood markers to predict colorectal cancer recurrence after surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the role of postoperative plasma ctDNA methylation markers in predicting the recurrence of colorectal cancer in patients who have undergone complete resection of peritoneal metastases. It involves collecting blood samples from participants to analyze ctDNA methylation status and correlating these findings with clinical outcomes over a follow-up period of at least 24 months. The study aims to enhance understanding of how these biomarkers can inform recurrence-free survival rates in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

-1. No gender limit, age greater than 18 years old; 2, ECOG score ≤1; 3. Life expectancy ≥2 years; 4. Colorectal adenocarcinoma/mucinous adenocarcinoma/signet ring cell carcinoma confirmed by histopathology; 5, preoperative PCI score ≤20, peritoneal tumor cytoreductive surgery (CRS), surgery to achieve R0/1 resection; 6. Be able to understand the situation of this study and sign the informed consent.

7\. The primary colorectal cancer has undergone R0 resection, and there is no extraperitoneal metastasis (except ovary).

Exclusion Criteria:

* 1\. Combined with primary malignant tumors of other organs (current or within the past 5 years) (excluding patients with skin basal cell carcinoma and cervical carcinoma in situ undergoing radical treatment); 2. Severe mental illness or drug abuse; 3, severe heart, lung, vascular disease can not tolerate surgery; 4. Pregnant or lactating women.

Where it's running

• Fudan University Shanghai Cancer Center
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Principal investigator: Guoxiang Cai — Fudan University
• Study coordinator: Guoxiang Cai, MD, PhD
• Email: hanlingyu_ann@sina.cn
• Phone: +86-18819431363

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.