Minocycline for moderate acute stroke at Maimonides

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, block‑randomized Phase 2/3 trial will enroll 1,164 adults with moderate stroke (NIHSS 5–20) who present within 24 hours of symptom onset at Maimonides Medical Center. Participants are assigned to receive either oral minocycline 200 mg once daily for five days plus standard stroke care, or standard care alone. Outcomes include NIHSS at discharge and 90 days, modified Rankin Scale (mRS) at discharge, 30 and 90 days, in-hospital and 90-day mortality, and monitoring for intracranial bleeding complications. The trial builds on prior single-center clinical experience and observational data suggesting possible neuroprotective and anti-inflammatory effects of minocycline.

Why it matters

Who can join: the full rules

\* Inclusion criteria

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Age \>/=18
2. NIHSS 5-20 \*National Institutes of Health Stroke Scale\*
3. Acute onset neurological deficit consistent with acute ischemic stroke or on imaging consistent with acute ischemia as defined by WHO \*(World Health Organization) \* guidelines or acute onset of neurological deficits with intracerebral Hemorrhage on imaging consistent with intracerebral bleed
4. The onset of neurological symptoms less than 24 hours

   * Exclusion criteria

An individual who meets any of the following criteria is excluded from participation in this study:

1. Clinically stroke is not suspected
2. Allergic to the Tetracycline group of medications or Intolerance to Minocycline
3. Pregnancy or suspected pregnancy or breastfeeding
4. Previous history of intolerance to Minocycline
5. Acute or chronic renal failure (stage III with GFR \*(Glomerular Filtration Rate) \* or Creatinine threshold)
6. Any patients with contraindications to undergo CT (Computed Tomography) / MRI (Magnetic Resonance Imaging)
7. Life expectancy less than one year or severe co-morbidities or comfort measure only (CMO) on admission
8. Pre-existing infectious disease requiring antibiotics
9. Inability to tolerate enteral medications/feeds
10. Patient/ family refusal

Where it's running

• Maimonides Medical Center
  Brooklyn, New York, United States Recruiting

Study contacts

• Principal investigator: Qingliang T. Wang, MD, PhD — Maimonides Medical Center
• Study coordinator: Qingliang T. Wang, MD, PhD
• Email: qwang@maimo.org
• Phone: 718.283.7670

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Psilocybin to reopen brain plasticity after chronic stroke

  This trial will test whether a supervised dose of psilocybin is safe and can help reopen brain plasticity in adults who had an ischemic or hemorrhagic stroke at least 12 months ago.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT07053917

• Deep phenotyping to explore recovery in young adults after stroke

  This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.

  Recruiting The Florey Institute of Neuroscience and Mental Health · Heidelberg, Victoria and 1 other locations · NCT07019493

• Stem cell therapy for chronic stroke recovery

  This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.

  Recruiting Phase 2 Hokkaido University Hospital · Sapporo, Hokkaido · NCT06752720

• AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

  This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.

  Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Leuven and 6 other locations · NCT07924371

• Web-based therapy using action observation and mirror therapy for arm weakness after stroke

  This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT07921108

• Remote Ischaemic Conditioning for Fatigue After Stroke 2

  Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.

  Recruiting Phase 2 Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire · NCT07914647

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.