Minimally invasive surgery for patients with impaired lung function

Non-intubated Thoracoscopic Surgery for Lung Leision in Patients With Impaired Pulmonary Function

This study is testing a new type of surgery that lets patients with weak lungs breathe on their own during the operation to see if it helps them recover better after surgery.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 30 (estimated)
• Ages: 14 Years to 85 Years
• Sex: All
• Sponsor: The Second Hospital of Shandong University (Academic / other)
• Locations: 1 site (Jinan, Shandong)
• Trial ID: NCT06848751 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates a non-intubated minimally invasive surgical approach for patients with impaired lung function who require surgical treatment for conditions such as lung cancer and pneumothorax. The method allows patients to maintain spontaneous breathing during the procedure, potentially reducing the need for postoperative intubation and ICU transfer. By avoiding endotracheal intubation, the trial aims to decrease the risks of airway injury and respiratory failure, thereby improving recovery outcomes. The study involves thorough preoperative assessments and multidisciplinary team discussions to ensure patient safety and suitability for the procedure.

Who should consider this trial

Good fit: Ideal candidates include patients with impaired lung function requiring minimally invasive lung surgery who can cooperate with perioperative care.

Not a fit: Patients with severe cardiopulmonary impairment or those unable to tolerate anesthesia or surgery will not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly reduce postoperative complications and improve recovery times for patients with compromised lung function.

How similar studies have performed: While this approach is innovative, similar non-intubated techniques have shown promise in other studies, suggesting potential for success.

Eligibility criteria

Inclusion Criteria:

1. Patients with impaired lung function (who may require postoperative intubation and transfer to the surgical ICU after preoperative and MDT discussions).
2. Patients requiring minimally invasive lung resection due to lung cancer, pulmonary nodules, benign lung tumors, pneumothorax, lung volume reduction surgery, etc.
3. Patients with normal mental status who can cooperate with perioperative examinations, exercises, and physical rehabilitation measures.
4. Patients who agree to participate in the clinical trial after communication.

Exclusion Criteria:

1. Patients with severe impairment of cardiopulmonary function or other organ systems, who are deemed unable to tolerate any form of anesthesia or minimally invasive surgery after preoperative and MDT discussions.
2. Patients with abnormal mental status or who are unable to adequately cooperate with perioperative examinations, exercises, and physical rehabilitation measures.
3. Patients who refuse to participate in the clinical trial or decline the use of non-intubated anesthesia with preserved spontaneous breathing.
4. Patients who refuse to undergo surgery.

Where this trial is running

Jinan, Shandong

• The Second Hospital of Shandong University — Jinan, Shandong, China (Recruiting)

Study contacts

• Principal investigator: Yunpeng Zhao — The Second Hospital of Shandong University
• Study coordinator: Yunpeng Zhao

Conditions Lung Function Decreased; Surgery