Using oscillometry to link body composition with airway tone and over‑reactivity
Official title: Body Composition Related Evaluation of Airway Tone and Hyper-rEactivity Using Oscillometry
Run by University of Rochester · NCT07356310 · Data updated 2026-11-12
We will test whether a quick oscillometry breathing test can show airway resistance and over‑reactivity related to body habitus in people referred for a methacholine challenge.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of Rochester Academic / other |
| Locations | 1 site (Rochester, New York) |
| Status | Recruiting |
| Started | February 17, 2026 |
| Main results expected | July 1, 2027 |
| Study ends | November 1, 2027 |
| Registry record updated | April 13, 2026 |
| Trial ID | NCT07356310 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
People referred for a methacholine challenge who can consent, speak and understand English, and perform oscillometry breathing tests are the ideal candidates.
✕Probably not a fit
People who cannot provide consent, cannot perform oscillometry, cannot travel to the Rochester site, or do not speak English are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will use oscillometry to measure airway resistance and reactance in people referred for methacholine challenge testing. Participants will undergo oscillometry and have their oscillometry results compared with methacholine responsiveness and measures of body composition or body habitus. The aim is to determine whether specific oscillometry patterns correlate with positive methacholine tests and with differences such as obesity. The study is conducted at the University of Rochester Medical Center and enrolls participants who can consent, speak English, and perform breathing tests.
Why it matters
Potential benefit: If successful, oscillometry could offer a quick, noninvasive way to detect airway hyper‑responsiveness and help personalize testing or treatment based on body habitus.
How similar studies have gone: Previous research has shown oscillometry can detect airway obstruction and some features of hyperreactivity, but using it specifically to link methacholine responsiveness with body composition is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Willingness to perform breathing test * Must be able to speak and understand English * Referred for Methacholine Challenge Test Exclusion Criteria: * Unable to provide consent or perform oscillometry test
Where it's running
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University of Rochester Medical Center
Rochester, New York, United States Recruiting
Study contacts
- Study coordinator: Patrick Donohue, MD
- Email: patrick_donohue@urmc.rochester.edu
- Phone: (585) 210-9301
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.