Using oscillometry to link body composition with airway tone and over‑reactivity
Body Composition Related Evaluation of Airway Tone and Hyper-rEactivity Using Oscillometry
We will test whether a quick oscillometry breathing test can show airway resistance and over‑reactivity related to body habitus in people referred for a methacholine challenge.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Rochester Academic / other |
| Locations | 1 site (Rochester, New York) |
| Trial ID | NCT07356310 on ClinicalTrials.gov |
What this trial studies
This observational study will use oscillometry to measure airway resistance and reactance in people referred for methacholine challenge testing. Participants will undergo oscillometry and have their oscillometry results compared with methacholine responsiveness and measures of body composition or body habitus. The aim is to determine whether specific oscillometry patterns correlate with positive methacholine tests and with differences such as obesity. The study is conducted at the University of Rochester Medical Center and enrolls participants who can consent, speak English, and perform breathing tests.
Who should consider this trial
Good fit: People referred for a methacholine challenge who can consent, speak and understand English, and perform oscillometry breathing tests are the ideal candidates.
Not a fit: People who cannot provide consent, cannot perform oscillometry, cannot travel to the Rochester site, or do not speak English are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, oscillometry could offer a quick, noninvasive way to detect airway hyper‑responsiveness and help personalize testing or treatment based on body habitus.
How similar studies have performed: Previous research has shown oscillometry can detect airway obstruction and some features of hyperreactivity, but using it specifically to link methacholine responsiveness with body composition is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Willingness to perform breathing test * Must be able to speak and understand English * Referred for Methacholine Challenge Test Exclusion Criteria: * Unable to provide consent or perform oscillometry test
Where this trial is running
Rochester, New York
- University of Rochester Medical Center — Rochester, New York, United States (Recruiting)
Study contacts
- Study coordinator: Patrick Donohue, MD
- Email: patrick_donohue@urmc.rochester.edu
- Phone: (585) 210-9301
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.