Microbial Profile of the Knee Joint During ACL Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study uses next-generation sequencing to analyze microbiological material from the knee during primary ACL reconstruction or revision surgery. It aims to identify bacteria that may be present without symptoms and could contribute to failure after ACL procedures. The study compares sequencing results with traditional culture methods to see if sequencing provides greater sensitivity for detecting infections. Eligibility is limited to adults undergoing ACL procedures who meet consent and language requirements, with several medical exclusion criteria to reduce risk. Primary site is Hôpital Privé Jean Mermoz in Lyon, France, led by GCS Ramsay Santé for Teaching and Research.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient undergoing primary ACL reconstruction or revision surgery
* Patient for whom access to the operative report of the primary ACL reconstruction is available
* Patient affiliated with or beneficiary of a social security system
* Patient who speaks French and has signed informed consent

Exclusion Criteria:

* Patients with preoperative signs or a history of knee joint infection
* Patients suffering from diabetes, cancer, or a chronic inflammatory disease
* Patients receiving immunosuppressive therapy
* Patients with elevated serum inflammatory markers
* Patients who have used intravenous drugs in the 3 months prior to surgery
* Patients who have used antibiotics in the 3 months prior to surgery
* Protected patients: adults under guardianship, curatorship, or other legal protection, persons deprived of their liberty by a judicial or administrative decision, persons under a protective measure, persons admitted to a health or social care facility for purposes other than research, and persons unable to express consent
* Pregnant or breastfeeding women

Where it's running

• Hôpital Privé Jean Mermoz
  Lyon, France Recruiting

Study contacts

• Study coordinator: Bertrand SONNERY-COTTET, MD
• Email: sonnerycottet@aol.com
• Phone: +33437530022

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Strength training with blood-flow restriction after ACL reconstruction

  This trial will test whether adding blood flow restriction to light strength training helps people recovering from ACL reconstruction regain muscle, strength, and knee function during outpatient rehabilitation.

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• Conventional rehabilitation with or without digital therapy to restore quadriceps activation after ACL reconstruction

  This trial tests whether adding a smartphone-based digital therapy to standard physiotherapy helps adults recovering from ACL reconstruction overcome quadriceps muscle inhibition.

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• Exercise with blood flow restriction for patients with complete ACL tears

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• Assessing soleus muscle strength in patients with ACL tears

  This study is testing the strength of a muscle in the calf of people with ACL tears to see how it compares to their uninjured leg and to healthy volunteers.

  Recruiting University of Liverpool · Liverpool · NCT06235736

• Optimizing graft selection for ACL reconstruction

  This study is testing which type of graft—quadriceps tendon, hamstring tendons, or patellar tendon—works best for helping young adults recover from their first ACL injury.

  Recruiting Hvidovre University Hospital · Hvidovre · NCT05342441

• Comparing quadriceps tendon and hamstring autografts for ACL reconstruction in young patients

  This study is testing whether using quadriceps tendon grafts instead of hamstring grafts for ACL surgery can lead to better recovery for young patients aged 10-18.

  Recruiting at 6 sites McMaster University · Hamilton, Ontario and 5 other locations · NCT03896464

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.