Optimizing graft selection for ACL reconstruction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the differences between three common methods for anterior cruciate ligament (ACL) reconstruction: using grafts from the quadriceps tendon, hamstring tendons, or patellar tendon. The study aims to provide a patient-centered and biomechanical perspective on how graft choice affects knee function, muscle strength, and overall surgical outcomes. By employing a randomized controlled design, 150 patients aged 18-40 with first-time ACL ruptures will be followed to assess the effectiveness of each graft type. The goal is to develop evidence-based, individualized treatment options for ACL injuries.

Why it matters

Who can join: the full rules

List of Inclusion criteria

* clinically confirmed first-time ACL rupture
* Current injury sustai´ned within 2 years
* high activity level prior to ACL rupture (Tegner score ≥ 3) and personal goal of returning to physical activity.

List of preoperative exclusion criteria

* Inadequate Danish language skills to answer questionnaires.
* Prior ligament surgery in the injured knee
* Prior ligament surgery in the non-injured knee
* Instability of the non-injured knee
* Known osteoarthritis (Kelgren Lawrence score ≥ 2)
* Prior open surgery to either knee
* Prior severe fracture involving knee joint surfaces
* Prior severe injury to thigh muscles in either leg (e.g. tear or compartment)
* Prior severe injury to the patella tendon of either knee (e.g. subluxation)
* Medical condition preventing full participation (e.g. active cancer, - rheumatoid arthritis)
* Psychiatric condition preventing full participation
* Pregnancy
* Obesity (BMI \> 30)

List of Perioperative exclusion criteria (Arthroscopy)

* Medial meniscus lesion \> 50%
* Lateral meniscus lesion \> 50%
* Treated Meniscal root lesion or radial meniscal tear that require restrictive regimen
* Cartilage lesion \>2cm2, Articular cartilage injury classification (ICRS) grade 3
* Concurrent ligament injury (except medial collateral ligament (MCL) lesion grade 1-2)

Where it's running

• Copenhagen University Hospital - Amger/Hvidovre
  Hvidovre, Denmark Recruiting

Study contacts

• Study coordinator: Merete B Speedtsberg, MSc
• Email: MSPE0006@regionh.dk
• Phone: +45 38622381

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Strength training with blood-flow restriction after ACL reconstruction

  This trial will test whether adding blood flow restriction to light strength training helps people recovering from ACL reconstruction regain muscle, strength, and knee function during outpatient rehabilitation.

  Recruiting University Hospital, Bonn · Bonn, North Rhine-Westphalia · NCT07043569

• Conventional rehabilitation with or without digital therapy to restore quadriceps activation after ACL reconstruction

  This trial tests whether adding a smartphone-based digital therapy to standard physiotherapy helps adults recovering from ACL reconstruction overcome quadriceps muscle inhibition.

  Recruiting GCS Ramsay Santé pour l'Enseignement et la Recherche · Lyon, France · NCT07030764

• Microbial Profile of the Knee Joint During ACL Surgery

  This study tests whether advanced DNA sequencing can detect hidden knee infections or microbiome changes in people undergoing ACL reconstruction or ACL revision surgery.

  Recruiting GCS Ramsay Santé pour l'Enseignement et la Recherche · Lyon · NCT07009392

• Exercise with blood flow restriction for patients with complete ACL tears

  This study is testing if exercising with blood flow restriction can help people with complete ACL tears recover better than just standard treatment alone.

  Recruiting at 2 sites European University Cyprus · Nicosia and 1 other locations · NCT06727344

• Assessing soleus muscle strength in patients with ACL tears

  This study is testing the strength of a muscle in the calf of people with ACL tears to see how it compares to their uninjured leg and to healthy volunteers.

  Recruiting University of Liverpool · Liverpool · NCT06235736

• Comparing quadriceps tendon and hamstring autografts for ACL reconstruction in young patients

  This study is testing whether using quadriceps tendon grafts instead of hamstring grafts for ACL surgery can lead to better recovery for young patients aged 10-18.

  Recruiting at 6 sites McMaster University · Hamilton, Ontario and 5 other locations · NCT03896464

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.