Measuring oxygen levels to predict complications during kidney treatment in critically ill patients
Continuous Central Venous Oxygen Saturation Measurement as a Tool to Predict Hemodynamic Instability Related to Renal Replacement Therapy in Critically Ill Patients
This study tests if measuring oxygen levels in critically ill patients can help predict problems during kidney treatment to improve their care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Montpellier Academic / other |
| Locations | 1 site (Montpellier) |
| Trial ID | NCT05897840 on ClinicalTrials.gov |
What this trial studies
This study investigates the use of continuous central venous oxygen saturation measurement to predict hemodynamic instability during renal replacement therapy in critically ill patients with acute kidney injury. The researchers hypothesize that a decrease in oxygen saturation can indicate a drop in cardiac output, potentially foreseeing complications such as intradialytic arterial hypotension. By continuously monitoring these oxygen levels during treatment, the study aims to develop preventive strategies to improve patient outcomes. The study will involve critically ill patients who are stable before starting renal replacement therapy.
Who should consider this trial
Good fit: Ideal candidates for this study are critically ill patients over 18 years old with severe acute kidney injury requiring renal replacement therapy and who are hemodynamically stable prior to treatment.
Not a fit: Patients who are pregnant, have chronic end-stage renal failure on dialysis, or have contraindications for venous catheter placement will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to better management of hemodynamic stability during renal replacement therapy, reducing complications and improving survival rates in critically ill patients.
How similar studies have performed: While there is limited literature on this specific approach, the concept of using oxygen saturation as a predictor for hemodynamic instability is a novel area of investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Critically ill patients requiring blood pressure monitoring * Severe AKI treated by RRT * Hemodynamic stability prior to initiation of RRT * Patients aged above 18 years Exclusion Criteria: * Pregnancy * Major under tutorship or curatorship * Refusal of the patient or trusted person/family (if present) to sign the informed consent or to confirm participation in the case of emergency inclusion * Patient is not beneficiary or affiliated with a social security plan * Contraindication to placement of a venous catheter in the superior vena cava territory: thrombosis of the superior vena cava, thrombosis of the jugular and subclavian veins * Chronic end-stage renal failure on chronic dialysis
Where this trial is running
Montpellier
- UH of Montpellier — Montpellier, France (Recruiting)
Study contacts
- Principal investigator: Eddine BENDIAB, Dr — Hospital of Montpellier
- Study coordinator: Eddine BENDIAB, Dr
- Email: e-bendiab@chu-montpellier.fr
- Phone: 0467332495
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.