Measuring muscle fatigue in people with cystic fibrosis using a mobile phone app
Reliability and Discriminant Validity of a Mobile App for Detecting Muscle Fatigue in People With Cystic Fibrosis
This project tests whether a mobile app can measure muscle tiredness during a one-minute sit-to-stand test in people with cystic fibrosis compared with healthy adults.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 68 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universidad Católica San Antonio de Murcia Academic / other |
| Locations | 1 site (Murcia, Murcia) |
| Trial ID | NCT07135869 on ClinicalTrials.gov |
What this trial studies
This observational study uses a mobile app that analyzes video of the one-minute sit-to-stand (1minSTS) test to derive time, velocity, and power as measures of fatigability. At least 34 people with cystic fibrosis and 34 matched healthy controls will perform chair rises for 60 seconds with measurements taken before, immediately after, and one minute after the test, alongside heart rate and Borg CR10 ratings. The protocol is repeated after 30 minutes to assess test-retest reliability, and differences between pre/post measures will quantify performance fatigability and recovery. Researchers will compare CF and control groups to see if fatigability remains elevated in contemporary CF care and whether the app provides reliable, low-cost measurements.
Who should consider this trial
Good fit: Ideal candidates are clinically stable adults with cystic fibrosis who are not on oxygen during testing, have had no medication changes or pulmonary exacerbations in the prior two weeks, and have no musculoskeletal issues or prior lung/liver transplant.
Not a fit: Patients with recent exacerbations or medication changes, those requiring oxygen during exercise, people with recent lung or liver transplants, or individuals with musculoskeletal conditions limiting chair rises are unlikely to benefit.
Why it matters
Potential benefit: If successful, the app could offer a low-cost, clinic-friendly way to monitor muscle fatigability in people with cystic fibrosis.
How similar studies have performed: Previous small studies and lab-based comparisons suggest video- or app-based sit-to-stand metrics can be reliable, but large, contemporary comparisons specifically in cystic fibrosis are novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinically stable. * No changes in medication or pulmonary exacerbations within the two weeks prior to inclusion. * Not requiring oxygen therapy during the test. * No history of lung or liver transplants. Exclusion Criteria: * Any musculoskeletal conditions that could limit or influence test performance.
Where this trial is running
Murcia, Murcia
- Asociación Murciana de Fibrosis Quistica — Murcia, Murcia, Spain (Recruiting)
Study contacts
- Principal investigator: Juan D Ruiz-Cárdenas, PhD — Universidad Católica San Antonio de Murcia
- Study coordinator: Juan D Ruiz-Cárdenas, PhD
- Email: jdruiz@ucam.edu
- Phone: +34 968 278 806
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.