Measuring lung overinflation with electrical impedance tomography in ventilated COPD patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll adults with moderate-to-severe COPD who require noninvasive or invasive mechanical ventilation and who can be monitored with an EIT belt. Continuous EIT recordings will be made during tidal ventilation and during clinician-directed PEEP titration; in intubated patients a low-flow pressure–volume maneuver with simultaneous EIT will be performed to derive one-lung PEEPi. Analyses will measure interlung insufflation delay and regional tidal distribution to detect asymmetry and overdistension between lungs. Data will be analyzed offline with dedicated software to reconstruct regional PV curves and estimate regional intrinsic PEEP.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients hospitalized in the ICU and who suffered moderate or severe COP (Gold 3 and 4)), with respiratory acidosis under NIV or intubated, and equipped with EIT over the age of 18.

Exclusion Criteria:

* Broncho-pleural leaks
* Pregnant or breastfeeding woman.
* Guardianship or curatorship
* Deprived of liberty
* No health insurance
* Impossibility to correctly position the EIT belt (e.g., dressings, chest drainage, etc.)
* Contra indications to EIT (e.g., implantable cardiac defibrillator, pacemaker, instable spinal lesions)

Where it's running

• Centre Hospitalier Côte Basque
  Bayonne, Centre Hospitalier de La Côte Basque, France Recruiting

Study contacts

• Study coordinator: Professor ROZE
• Email: hroze@ch-cotebasque.fr
• Phone: +33559443535

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Understanding immune patterns and ECMO strategies to help adults with severe ARDS

  This study tests how different immune and clinical patterns in adults with moderate-to-severe ARDS respond to ECMO and lung-protective care, aiming to improve outcomes.

  Recruiting at 16 sites Southeast University, China · Beijing, Beijing Municipality and 38 other locations · NCT07726940

• Optimal corticosteroid dosing for ARDS: short vs. prolonged therapy

  This trial tests different corticosteroid doses and treatment lengths to see which helps adults with ARDS who are on ventilators.

  Recruiting Phase 4 National Taiwan University Hospital · Taipei · NCT07711964

• Lateral positioning to optimize breathing in adults after abdominal surgery with ARDS

  This study tests whether lying on the left or right side helps improve lung function in adults who developed ARDS after abdominal surgery, using a bedside imaging test to watch ventilation and blood flow while changing positions.

  Recruiting Ruijin Hospital · Shanghai · NCT07669558

• Dexamethasone for sepsis-related ARDS in adults on ventilatory support

  This trial tests whether dexamethasone can help adults with sepsis-associated ARDS on ventilators recover better compared to placebo.

  Recruiting Phase 3 Southeast University, China · Nanjing, Jiangsu and 1 other locations · NCT07576660

• NIRS for EDResp: Which first helps hypoxemic adults best?

  This trial tests whether non-invasive ventilation with a mask (NIPPV) or high-flow nasal oxygen (HFNO) is more helpful for adults in the emergency department with acute hypoxemic respiratory failure.

  Recruiting at 9 sites Ohio State University · Tucson, Arizona and 8 other locations · NCT07558265

• Sodium bicarbonate with bedside electrical impedance tomography to map lung blood flow in ventilated adults

  This project will try whether a small sodium bicarbonate injection combined with bedside electrical impedance tomography can map lung blood flow in adults on mechanical ventilation, compared with hypertonic saline.

  Recruiting First Affiliated Hospital of Wannan Medical College · Wuhu, Anhui · NCT07542366

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.