Matching cancer patients with targeted therapies based on their molecular profiles
Official title: Bergonie Institut Profiling : Fighting Cancer by Matching Molecular Alterations and Drugs in Early Phase Trials
Run by Institut Bergonié · NCT02534649 · Data updated 2026-11-12
This study is testing whether matching cancer patients with targeted treatments based on their unique genetic profiles can improve their chances of getting better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 10000 (estimated) |
| Sponsor | Institut Bergonié Academic / other |
| Drugs / interventions | immunotherapy |
| Locations | 7 sites (Bayonne and 6 other locations) |
| Status | Recruiting |
| Started | December 2015 |
| Main results expected | March 2028 |
| Study ends | December 2029 |
| Registry record updated | October 8, 2026 |
| Trial ID | NCT02534649 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with advanced solid tumors or hematological malignancies.
✕Probably not a fit
Patients who are pregnant, breastfeeding, or have been previously enrolled in this study may not receive any benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to personalize cancer treatment by identifying actionable molecular alterations in patients with advanced solid tumors or hematological malignancies. Using next-generation sequencing and immunological profiling, the study will analyze tumor and blood samples to create a comprehensive molecular profile for each patient. This profile will help clinicians match patients to specific early phase clinical trials that are most likely to benefit them based on their unique genetic characteristics.
Why it matters
Potential benefit: If successful, this approach could lead to more effective and tailored cancer treatments for patients with advanced disease.
How similar studies have gone: Other studies utilizing personalized medicine approaches have shown promise, indicating potential success for this novel methodology.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 18 years, 2. Histology: solid malignant tumor or hematological malignancy, 3. Deleted MSA9 4. Deleted MSA9, 5. Deleted MSA9, 6. Deleted MSA9, 7. Patient with a social security in compliance with the French law relating to biomedical research (Article L.1121-11 of French Public Health Code), 8. Voluntary signed and dated written informed consent prior to any study specific procedure. Exclusion Criteria: 1. Deleted MSA9 2. Deleted MSA9 3. Deleted MSA9 4. Deleted MSA9 5. Deleted MSA9 6. Deleted MSA9 7. Deleted MSA9 8. Deleted MSA9 9. Individuals deprived of liberty or placed under guardianship 10. Pregnant or breast feeding women, 11. Previous enrolment in the present study.
Where it's running
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Centre Hospitalier de la Côte Basque
Bayonne, France Recruiting -
Clinique Tivoli-Ducos
Bordeaux, France Recruiting -
Institut Bergonie
Bordeaux, France Recruiting -
Polyclinique Bordeaux Nord Aquitaine
Bordeaux, France Recruiting -
Clinique Marzet
Pau, France Recruiting -
Centre Hospitalier de Pau
Pau, France Not yet recruiting
Show 1 more location
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Centre Eugène Marquis
Rennes, France Active not recruiting
Study contacts
- Study coordinator: Antoine ITALIANO, MD, PhD
- Email: a.italiano@bordeaux.unicancer.fr
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.