Mapping the HLA genomic region in the Greek population
A Clinical Study to Map the HLA GENomic Region and Its potEntial aSsocIation With Selected diSeases in the Greek Population
This study is trying to create a map of genetic differences in the Greek population to see how they might relate to different diseases.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 12000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Athens LifeTech Park Academic / other |
| Locations | 8 sites (Chaïdári, Attica and 7 other locations) |
| Trial ID | NCT06227468 on ClinicalTrials.gov |
What this trial studies
The GENESIS study aims to create a pilot map of HLA genetic variation in the Greek population and explore potential correlations with various diseases. This multicenter, prospective, non-interventional study will involve 12,000 adult participants who will provide demographic information and undergo genetic sampling through buccal swabs. The collected DNA will be analyzed for HLA genotyping to facilitate future medical research and clinical applications. The study is designed to last for 36 months and will take place across multiple hospitals and clinics in Greece.
Who should consider this trial
Good fit: Ideal candidates are Greek adults aged 18 and older who are visiting hospitals or clinics in Greece and can provide informed consent.
Not a fit: Patients who have undergone certain types of transplants or those unable to provide informed consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of genetic factors related to diseases prevalent in the Greek population, potentially leading to improved diagnostics and treatments.
How similar studies have performed: While mapping HLA regions has been explored in other populations, this specific study is novel in its focus on the Greek population.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: The study will include adult subjects (age ≥ 18) that: * possess a Greek social security number and are visiting hospitals/clinics, and/or other private laboratory institutions (incl. clinics and health care groups) as part of standard clinical practice in Greece, * are willing and able to provide written informed consent to participate in the study according to the study protocol. Exclusion Criteria: * Subjects not able to provide written informed consent (e.g. ICU patients, mental illness patients, lack of legal capacity). * Subjects who have had an allogeneic (non-self-donor): * bone marrow transplant * stem cell transplant * blood transfusion less than two weeks prior to buccal swab sample collection * liver transplant * Subjects who participated in an interventional clinical trial in the past that according to the subject's physician opinion might have had an impact on their HLA genome.
Where this trial is running
Chaïdári, Attica and 7 other locations
- 2nd Propaedeutic Department of Internal Medicine, Attikon University General Hospital — Chaïdári, Attica, Greece (Not_yet_recruiting)
- 2nd Department of Neurology, AHEPA University Hospital — Thessaloniki, Thessaloniki, Greece (Not_yet_recruiting)
- Department of Respiratory Medicine, University General Hospital of Alexandroupolis — Alexandroupoli, Thrace, Greece (Recruiting)
- Department of Infectious Diseases, 2nd Department of Internal Medicine, University General Hospital of Alexandroupolis — Alexandroupoli, Greece (Recruiting)
- Department of Cardiology, University General Hospital of Heraklion — Heraklion, Greece (Not_yet_recruiting)
- Department of Rheumatology, University Hospital of Heraklion — Heraklion, Greece (Not_yet_recruiting)
- Department of Respiratory, University Hospital of Ioannina — Ioannina, Greece (Recruiting)
- Department of Haematology, University General Hospital of Larissa — Larissa, Greece (Not_yet_recruiting)
Study contacts
- Study coordinator: Efi Giannopoulou
- Email: egiannopoulou@lifetechpark.com
- Phone: +306974784009
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.