Magnesium plus L-carnitine for metabolic and hormonal symptoms in women with PCOS
Official title: Assessment of the Effect of Magnesium and Levocarnitine Co-supplementation on Lipid Profile, Glycemic Control Indicators and Hirsutism in Women With Polycystic Ovarian Syndrome
Run by Science & Research Islamic Azad University Branch Khozestan · NCT07298564 · Data updated 2026-11-12
This 12-week test will see if taking magnesium together with L-carnitine improves blood sugar, cholesterol, and excess hair in women aged 19–65 with PCOS.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 19 Years to 65 Years |
| Sex | Women only |
| Enrollment | 84 (estimated) |
| Sponsor | Science & Research Islamic Azad University Branch Khozestan Academic / other |
| Locations | 1 site (Tehran, Tehran Province) |
| Status | Recruiting |
| Started | January 30, 2026 |
| Main results expected | October 30, 2026 |
| Study ends | November 30, 2026 |
| Registry record updated | December 23, 2025 |
| Trial ID | NCT07298564 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 19–65 with PCOS diagnosed by Rotterdam criteria who are not pregnant or breastfeeding and do not have major liver, kidney, thyroid, neurological, or psychiatric disorders and are not taking therapeutic vitamin/mineral supplements.
✕Probably not a fit
Women who are menopausal, pregnant or breastfeeding, have hypothyroidism, significant liver or kidney disease, seizure or neuromuscular disorders, or who already take therapeutic supplements are unlikely to be eligible or to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, triple-blind, parallel-group trial will enroll 84 women aged 19–65 diagnosed with PCOS by Rotterdam criteria and randomly assign them to magnesium (500 mg/day), L-carnitine (1000 mg/day), or placebo for 12 weeks. Primary measurements include BMI, waist circumference, blood pressure, fasting blood sugar, HbA1c, lipid profile, serum insulin, calculated insulin resistance, and hirsutism, taken at baseline and at the end of the intervention. Key exclusions include pregnancy or breastfeeding, menopause, hypothyroidism, significant liver or kidney disease, seizure or neuromuscular disorders, psychiatric conditions, and current therapeutic vitamin/mineral supplements. Outcomes will be compared between groups to determine whether supplementation produces greater metabolic or hormonal improvement than placebo.
Why it matters
Potential benefit: If successful, the combination could provide a low-cost, well-tolerated option to improve insulin sensitivity, lipid profiles, and reduce hirsutism in women with PCOS.
How similar studies have gone: Prior small studies of magnesium or L-carnitine alone have reported modest improvements in insulin resistance and lipid measures, but combined supplementation in PCOS is less well studied and remains relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 19 and 65 years. * Diagnosis of polycystic ovary syndrome (PCOS) according to the Rotterdam criteria. Exclusion Criteria: * Hypothyroidism * Menopause * Pregnancy or breastfeeding * Renal (kidney) dysfunction * Use of therapeutic vitamin or mineral supplements * Liver diseases (e.g., grade 3 fatty liver, hepatitis, or cirrhosis) * Psychiatric disorders such as bipolar disorder * Neuromuscular diseases (e.g., myasthenia gravis, Parkinson's disease, multiple sclerosis, epilepsy, or muscular dystrophy) * History of seizures * Participants who become pregnant during the study or fail to comply with more than 20% of the study protocol will be withdrawn from the study
Where it's running
-
Tara Momeni
Tehran, Tehran Province, Iran Recruiting
Study contacts
- Study coordinator: Behnood Abbasi
- Email: abbasi.b@srbiau.ac.ir
- Phone: +9821 44864929
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.