Differences in Functional Capacity in Knee Osteoarthritis with Similar Pain
Official title: Evaluation of Functional Capacity Heterogeneity in Patients With Knee Osteoarthritis and Similar Pain Severity
Run by Mardin Artuklu University · NCT07869680 · Data updated 2026-11-12
This study tests factors that might explain why people with knee osteoarthritis and similar pain levels have different abilities to walk, stand, and perform daily tasks.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 40 Years to 75 Years |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | Mardin Artuklu University Academic / other |
| Locations | 1 site (Mardin) |
| Status | Recruiting |
| Started | August 1, 2026 |
| Main results expected | May 1, 2027 |
| Study ends | May 1, 2027 |
| Registry record updated | October 9, 2026 |
| Trial ID | NCT07869680 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 40–75 with radiographic knee OA (Kellgren-Lawrence grade 2–3) and average knee pain 4–6/10 in the past week.
✕Probably not a fit
Participants with extreme comorbidities or non-ambulatory status may not contribute to functional capacity analyses.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with radiographic knee osteoarthritis and moderate pain (4–6/10) visit once to complete questionnaires on function, central sensitization, and activity, then perform a short walk, chair stand, and Timed Up and Go tests. The researchers will analyze how demographics, radiographic severity, sensory symptom burden, and activity relate to functional capacity, using regression and group comparisons by functional reserve. The goal is to identify factors beyond pain that influence how well people function in daily life.
Why it matters
Potential benefit: If successful, findings could help tailor nonpharmacologic strategies to improve daily function for people with knee OA who have similar pain but different functional abilities.
How similar studies have gone: Previous work has linked central sensitization and activity levels to function in OA, but this study uniquely analyzes functional reserve within a similar pain range.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 40-75 years * Clinical and radiographic diagnosis of knee osteoarthritis * Kellgren-Lawrence grade 2 or 3 knee osteoarthritis * Knee pain lasting at least 3 months * Average knee pain intensity during the previous week between 4 and 6 on a 0-10 visual analog scale * Ability to provide written informed consent Exclusion Criteria: * Kellgren-Lawrence grade 1 or 4 knee osteoarthritis * Inflammatory rheumatic disease * History of knee surgery or intra-articular knee injection within the previous 6 months * Neurological disease that substantially affects knee function * Severe cardiopulmonary disease that prevents walking or performance testing * Cognitive impairment that prevents participation in the assessment procedures * For participants with bilateral knee osteoarthritis, assessments will be performed on the more painful knee.
Where it's running
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Mardin Training and Research Hospital
Mardin, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Taha Yasin YILDIRIM, M.D.
- Email: tyasinyildirim.ftr@gmail.com
- Phone: +90 534 220 77 17
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.