Lycium barbarum polysaccharide for dry eye symptoms in adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study tests whether oral Lycium barbarum polysaccharide (LBP) can improve symptoms and clinical signs of dry eye disease in adults. Participants will take LBP twice daily for 12 weeks and attend visits at baseline, 4 weeks, and 12 weeks for questionnaires and eye examinations measuring tear film, tear production, and ocular surface health. The study will provide preliminary data on safety and potential benefits to guide future larger trials. It employs standardized optometric assessments in a clinical research setting to characterize changes over time. Outcomes will inform whether further investigation in a controlled trial is warranted.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 to 60 years at enrollment.
* Clinical diagnosis of dry eye disease, defined as OSDI-12 score \>=13 and at least one clinical sign of dry eye disease.
* Habitual visual acuity 6/9 or better in both eyes.
* Able to understand the study procedures and provide written informed consent.

Exclusion Criteria:

* Ocular infection within 3 months before enrollment or ocular disease other than dry eye disease.
* History of ocular surgery, including refractive surgery.
* Use of dry eye-related products, such as artificial tears, within 1 month before enrollment.
* Contact lens wear within 1 month before enrollment.
* Long-term use of medications known to affect dry eye symptoms.
* Severe or unstable systemic disease.
* Infectious disease, such as viral influenza.
* Known allergy or hypersensitivity to Lycium barbarum polysaccharide.
* Pregnant or breastfeeding.
* Any condition that, in the investigator's judgment, makes the participant unsuitable for the study.

Where it's running

• The Hong Kong Polytechnic University, School of Optometry, Optometry Clinic
  Hong Kong, Hong Kong, Hong Kong Recruiting

Study contacts

• Study coordinator: Thomas C LAM, PhD
• Email: thomas.c.lam@polyu.edu.hk
• Phone: +852 27666115

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.