Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Using Platelet-Rich Plasma to Treat Severe Dry Eye Syndrome

Official title: Efficacy of Restoration of Lacrimal Secretion After Injection of Platelet-Rich Plasma (PRP) Into the Lacrimal Gland in Severe Dry Eye Syndromes (ReLIPSSO)

Run by Centre Hospitalier Universitaire de Nice · NCT06831253 · Data updated 2026-11-12

This study is testing if injecting Platelet-Rich Plasma into the tear glands can help people with severe dry eye syndrome produce more tears and feel better.

More Dry Eye Syndromes trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment20 (estimated)
SponsorCentre Hospitalier Universitaire de Nice
Academic / other
Locations1 site (Nice, Site Principal Investigator)
StatusRecruiting
StartedMarch 17, 2025
Main results expectedMarch 1, 2026
Study endsJuly 1, 2026
Registry record updatedMarch 19, 2025
Trial IDNCT06831253 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals diagnosed with severe dry keratoconjunctivitis and meeting specific platelet and clotting factor standards.

Probably not a fit

Patients with significant fibrosis of the conjunctival portion of the lacrimal gland or complete stenosis of both lacrimal meatus in the treated eye may not benefit from this treatment.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of injecting Platelet-Rich Plasma (PRP) into the lacrimal gland to enhance tear production in patients suffering from severe dry eye syndrome due to aqueous deficiency. Participants will receive four PRP injections during the study period. The goal is to determine if this treatment can restore normal lacrimal secretion and alleviate symptoms associated with dry eye conditions.

Why it matters

Potential benefit: If successful, this treatment could significantly improve the quality of life for patients suffering from severe dry eye syndrome.

How similar studies have gone: While the use of Platelet-Rich Plasma in various medical fields has shown promise, this specific application in treating dry eye syndrome is relatively novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Platelet counts, and clotting factors in the standarts
* Presenting with severe dry keratoconjunctivitis diagnosed by an ophthalmologist

Exclusion Criteria:

* Patients with significant fibrosis of the conjunctival portion of the lacrimal gland
* Patients with complete stenosis of both lacrimal meatus in the treated eye

Where it's running

  • CHU de Nice
    Nice, Site Principal Investigator, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.