Using Platelet-Rich Plasma to Treat Severe Dry Eye Syndrome
Official title: Efficacy of Restoration of Lacrimal Secretion After Injection of Platelet-Rich Plasma (PRP) Into the Lacrimal Gland in Severe Dry Eye Syndromes (ReLIPSSO)
Run by Centre Hospitalier Universitaire de Nice · NCT06831253 · Data updated 2026-11-12
This study is testing if injecting Platelet-Rich Plasma into the tear glands can help people with severe dry eye syndrome produce more tears and feel better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice, Site Principal Investigator) |
| Status | Recruiting |
| Started | March 17, 2025 |
| Main results expected | March 1, 2026 |
| Study ends | July 1, 2026 |
| Registry record updated | March 19, 2025 |
| Trial ID | NCT06831253 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals diagnosed with severe dry keratoconjunctivitis and meeting specific platelet and clotting factor standards.
✕Probably not a fit
Patients with significant fibrosis of the conjunctival portion of the lacrimal gland or complete stenosis of both lacrimal meatus in the treated eye may not benefit from this treatment.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of injecting Platelet-Rich Plasma (PRP) into the lacrimal gland to enhance tear production in patients suffering from severe dry eye syndrome due to aqueous deficiency. Participants will receive four PRP injections during the study period. The goal is to determine if this treatment can restore normal lacrimal secretion and alleviate symptoms associated with dry eye conditions.
Why it matters
Potential benefit: If successful, this treatment could significantly improve the quality of life for patients suffering from severe dry eye syndrome.
How similar studies have gone: While the use of Platelet-Rich Plasma in various medical fields has shown promise, this specific application in treating dry eye syndrome is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Platelet counts, and clotting factors in the standarts * Presenting with severe dry keratoconjunctivitis diagnosed by an ophthalmologist Exclusion Criteria: * Patients with significant fibrosis of the conjunctival portion of the lacrimal gland * Patients with complete stenosis of both lacrimal meatus in the treated eye
Where it's running
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CHU de Nice
Nice, Site Principal Investigator, France Recruiting
Study contacts
- Study coordinator: Doctor Jean Philippe GROSSE, Dr
- Email: causeret.m@chu-nice.fr
- Phone: 04.92.03.47.02
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.