Comparing tear structure in menopausal and non-menopausal women
Official title: Difference of Tear Ferning Between Pre-and Post-menopausal Women and Between Post-menopausal Women with or Without Hormone Replacement Therapy (HRT)
Run by Chung Shan Medical University · NCT06848829 · Data updated 2026-11-12
This study is testing how menopause affects tear quality and production in women, including those on hormone therapy, to see if there are differences between pre-menopausal and post-menopausal women.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 65 Years |
| Sex | Women only |
| Enrollment | 90 (estimated) |
| Sponsor | Chung Shan Medical University Academic / other |
| Locations | 1 site (Taichung, Taiwan) |
| Status | Recruiting |
| Started | October 1, 2024 |
| Main results expected | September 1, 2025 |
| Study ends | October 1, 2025 |
| Registry record updated | February 27, 2025 |
| Trial ID | NCT06848829 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 20 to 65, both pre-menopausal and post-menopausal.
✕Probably not a fit
Patients with existing ocular diseases or those in vulnerable groups may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study analyzes the differences in tear ferning patterns between pre-menopausal and post-menopausal women, including those receiving hormone replacement therapy. It involves collecting tear and blood samples to perform an enzyme-linked immunosorbent assay related to menopause. Additionally, measurements of tear volume, osmolarity, intraocular pressure, and tear break-up time are conducted to assess dry eye conditions. The goal is to better understand how menopause affects tear production and quality.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic methods for dry eye syndromes in menopausal women.
How similar studies have gone: While there is limited data on this specific approach, studies on tear ferning and menopause have shown promising results in understanding dry eye conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged between 20 and 65 years Exclusion Criteria: * No evident ocular diseases such as cornea, cataracts, vitreous degeneration, glaucoma, and retinopathy. * Belong to vulnerable groups(pregnancy woman, prisoner, ethical minorities, economic or educationally disadvantaged subjects, disabled individuals such as those at terminal stage of tumorigenesis, blindness, terminal ill individuals)
Where it's running
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Jen-Ai Hospital
Taichung, Taiwan, Taiwan Recruiting
Study contacts
- Study coordinator: David P Lin, PhD
- Email: pcl@csmu.edu.tw
- Phone: 886-910-371286
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.