Clinical trial Recruiting at 1 site Interventional Ages 20 to 65 Women only

Comparing tear structure in menopausal and non-menopausal women

Official title: Difference of Tear Ferning Between Pre-and Post-menopausal Women and Between Post-menopausal Women with or Without Hormone Replacement Therapy (HRT)

Run by Chung Shan Medical University · NCT06848829 · Data updated 2026-11-12

This study is testing how menopause affects tear quality and production in women, including those on hormone therapy, to see if there are differences between pre-menopausal and post-menopausal women.

Quick facts

Study typeInterventional
Ages20 Years to 65 Years
SexWomen only
Enrollment90 (estimated)
SponsorChung Shan Medical University
Academic / other
Locations1 site (Taichung, Taiwan)
StatusRecruiting
StartedOctober 1, 2024
Main results expectedSeptember 1, 2025
Study endsOctober 1, 2025
Registry record updatedFebruary 27, 2025
Trial IDNCT06848829 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are women aged 20 to 65, both pre-menopausal and post-menopausal.

Probably not a fit

Patients with existing ocular diseases or those in vulnerable groups may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study analyzes the differences in tear ferning patterns between pre-menopausal and post-menopausal women, including those receiving hormone replacement therapy. It involves collecting tear and blood samples to perform an enzyme-linked immunosorbent assay related to menopause. Additionally, measurements of tear volume, osmolarity, intraocular pressure, and tear break-up time are conducted to assess dry eye conditions. The goal is to better understand how menopause affects tear production and quality.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnostic methods for dry eye syndromes in menopausal women.

How similar studies have gone: While there is limited data on this specific approach, studies on tear ferning and menopause have shown promising results in understanding dry eye conditions.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Aged between 20 and 65 years

Exclusion Criteria:

* No evident ocular diseases such as cornea, cataracts, vitreous degeneration, glaucoma, and retinopathy.
* Belong to vulnerable groups(pregnancy woman, prisoner, ethical minorities, economic or educationally disadvantaged subjects, disabled individuals such as those at terminal stage of tumorigenesis, blindness, terminal ill individuals)

Where it's running

  • Jen-Ai Hospital
    Taichung, Taiwan, Taiwan
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.