Lung cancer screening program for high-risk individuals in Mexico
Official title: Lung Cancer Early Detection With Low-dose Computed Tomography in High-risk Individuals: Experience in Mexico
Run by Instituto Nacional de Cancerologia de Mexico · NCT06535451 · Data updated 2026-11-12
This study is testing a lung cancer screening program for high-risk people in Mexico, like heavy smokers and those with COPD, to see if regular scans and tests can help catch cancer early.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 50 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Instituto Nacional de Cancerologia de Mexico Academic / other |
| Locations | 1 site (Mexico City, Tlalpan) |
| Status | Recruiting |
| Started | March 24, 2022 |
| Main results expected | March 24, 2026 |
| Study ends | March 24, 2027 |
| Registry record updated | December 24, 2025 |
| Trial ID | NCT06535451 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals over 50 years old who are current or former heavy smokers, non-smokers exposed to wood smoke, or those diagnosed with COPD.
✕Probably not a fit
Patients with a history of any type of cancer within the last five years or those unable to undergo tomography due to physical limitations may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to detect early-stage lung cancer in Mexican individuals aged 50 and older who are current or former heavy smokers, non-smokers exposed to significant wood smoke, or diagnosed with COPD. Participants will undergo annual low-dose computed tomography (LDCT) scans, lung function tests, and serum biomarker assessments over three years, with follow-up lasting up to ten years. The study also seeks to evaluate the psychological impact of screening and the association of lung cancer with immunologic biomarkers.
Why it matters
Potential benefit: If successful, this program could lead to earlier detection of lung cancer, improving treatment outcomes and survival rates for high-risk populations.
How similar studies have gone: Other studies have shown success with similar lung cancer screening approaches, particularly using low-dose CT in high-risk populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Eligible participants over fifty years old and one of the next criteria: * Current smokers (\>20 pack-years) * Former smokers (\>20 pack-years) who have quit within the past 15 years, * Non-smokers exposed to wood smoke more than 100 hours/year * Patients diagnosed with Chronic Obstructive Pulmonary Disease (COPD). Exclusion Criteria: * Subjects who cannot be examined by tomography due to physical limitations such as weight. * History of any type of cancer within the last five years, except non-melanoma skin cancer. * Symptoms consistent with some malignant neoplasm. * People with a poor physical-emotional condition that reduces their life expectancy or does not ensure adherence to the study. Elimination Criteria • Withdrawal of informed consent
Where it's running
-
Instituto Nacional de Cancerologia (INCan) Mexico
Mexico City, Tlalpan, Mexico Recruiting
Study contacts
- Principal investigator: Oscar G Arrieta, M.D., M.Sc. — Instituto Nacional de Cancerologia (INCan) Mexico
- Study coordinator: Oscar G Arrieta, M.D., M.Sc.
- Email: ogarrieta@gmail.com
- Phone: 5556280400
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.