Lung cancer screening program for high-risk individuals in Mexico
Lung Cancer Early Detection With Low-dose Computed Tomography in High-risk Individuals: Experience in Mexico
This study is testing a lung cancer screening program for high-risk people in Mexico, like heavy smokers and those with COPD, to see if regular scans and tests can help catch cancer early.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | Instituto Nacional de Cancerologia de Mexico Academic / other |
| Locations | 1 site (Mexico City, Tlalpan) |
| Trial ID | NCT06535451 on ClinicalTrials.gov |
What this trial studies
This observational study aims to detect early-stage lung cancer in Mexican individuals aged 50 and older who are current or former heavy smokers, non-smokers exposed to significant wood smoke, or diagnosed with COPD. Participants will undergo annual low-dose computed tomography (LDCT) scans, lung function tests, and serum biomarker assessments over three years, with follow-up lasting up to ten years. The study also seeks to evaluate the psychological impact of screening and the association of lung cancer with immunologic biomarkers.
Who should consider this trial
Good fit: Ideal candidates include individuals over 50 years old who are current or former heavy smokers, non-smokers exposed to wood smoke, or those diagnosed with COPD.
Not a fit: Patients with a history of any type of cancer within the last five years or those unable to undergo tomography due to physical limitations may not benefit from this study.
Why it matters
Potential benefit: If successful, this program could lead to earlier detection of lung cancer, improving treatment outcomes and survival rates for high-risk populations.
How similar studies have performed: Other studies have shown success with similar lung cancer screening approaches, particularly using low-dose CT in high-risk populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Eligible participants over fifty years old and one of the next criteria: * Current smokers (\>20 pack-years) * Former smokers (\>20 pack-years) who have quit within the past 15 years, * Non-smokers exposed to wood smoke more than 100 hours/year * Patients diagnosed with Chronic Obstructive Pulmonary Disease (COPD). Exclusion Criteria: * Subjects who cannot be examined by tomography due to physical limitations such as weight. * History of any type of cancer within the last five years, except non-melanoma skin cancer. * Symptoms consistent with some malignant neoplasm. * People with a poor physical-emotional condition that reduces their life expectancy or does not ensure adherence to the study. Elimination Criteria • Withdrawal of informed consent
Where this trial is running
Mexico City, Tlalpan
- Instituto Nacional de Cancerologia (INCan) Mexico — Mexico City, Tlalpan, Mexico (Recruiting)
Study contacts
- Principal investigator: Oscar G Arrieta, M.D., M.Sc. — Instituto Nacional de Cancerologia (INCan) Mexico
- Study coordinator: Oscar G Arrieta, M.D., M.Sc.
- Email: ogarrieta@gmail.com
- Phone: 5556280400
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.