Lung cancer screening for workers exposed to harmful substances

LUng Cancer Screening With Low-dose Computed Tomography in a Population Exposed to Occupational Lung Carcinogens

This study is testing if low-dose chest CT scans can help find lung cancer early in smokers aged 55 to 74 who have been exposed to harmful substances at work.

Quick facts

• Study type: Observational
• Enrollment: 6000 (estimated)
• Ages: 55 Years to 74 Years
• Sex: All
• Sponsor: Centre Hospitalier Intercommunal Creteil (other)
• Locations: 8 sites (Bordeaux and 7 other locations)
• Trial ID: NCT03562052 on ClinicalTrials.gov

What this trial studies

This study evaluates the feasibility of lung cancer screening using low-dose chest CT scans in a high-risk population of smokers aged 55 to 74 who have been exposed to occupational lung carcinogens. It aims to assess the organization of screening activities, the validity of self-administered questionnaires for identifying high-risk individuals, and the effectiveness of lung cancer detection methods. The study will also monitor smoking cessation rates among participants over a two-year period.

Who should consider this trial

Good fit: Ideal candidates are current or former smokers aged 55 to 74 with significant occupational exposure to known lung carcinogens.

Not a fit: Patients with a history of lung cancer, serious comorbidities, or those who have not been exposed to occupational carcinogens will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved early detection of lung cancer in high-risk workers, potentially saving lives.

How similar studies have performed: Other studies have shown success with lung cancer screening in high-risk populations, indicating that this approach is promising.

Eligibility criteria

Inclusion Criteria:

Subjects at high risk of lung cancer: current smokers smoking 30 pack-years or more or ex-smokers smoking 30 pack-years or more and who have quit smoking for less than 15 years and currently or previously occupationally exposed to lung carcinogens. With an algorithm for determination of minimal duration of exposure to occupational carcinogens (according to the type and duration of occupational lung carcinogens)

Exclusion Criteria:

* Presence of clinical signs of lung cancer
* Subjects with a history of lung cancer
* Presence of serious short-term life-threatening comorbidities
* Absence of occupational exposure to lung carcinogens according to the predefined criteria
* Subjects already included in another prospective cohort study
* Subjects already assessed by chest CT scan during the previous year
* No tobacco exposure or insufficient tobacco exposure or smoking cessation for more than 15 years.

Where this trial is running

Bordeaux and 7 other locations

• Centre Hospitalier Universitaire de Bordeaux — Bordeaux, France (RECRUITING)
• Université de Bordeaux — Bordeaux, France (ACTIVE_NOT_RECRUITING)
• Centre Hospitalier Universitaire de Brest — Brest, France (NOT_YET_RECRUITING)
• Centre Hospitalier Universitaire de Caen — Caen, France (NOT_YET_RECRUITING)
• Centre Hospitalier Intercommunal de Créteil — Créteil, France (RECRUITING)
• Centre Hospitalier Universitaire de Rennes — Rennes, France (NOT_YET_RECRUITING)
• Centre Hospitalier Universitaire de Rouen — Rouen, France (NOT_YET_RECRUITING)
• Hôpital d'Instruction des Armées Sainte-Anne — Toulon, France (NOT_YET_RECRUITING)

Study contacts

• Principal investigator: Jean-Claude Pairon, Pr — Centre Hospitalier Interconnmunal de Créteil
• Study coordinator: Jean-Claude Pairon, Pr

Conditions: Lung Cancer, Cancer, Lung, Occupational carcinogens, Tobacco smoking, Screening, Chest CT Scan, Asbestos