Combining Ketamine and Magnesium for Pain Relief After Nose Surgery
Effectiveness of Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Patients Undergoing Open Rhinoplasty: A Randomized Controlled Trial
This study is testing whether combining ketamine and magnesium during nose surgery can help reduce pain and lower the need for opioids afterward.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06966518 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of using a combination of ketamine and magnesium sulfate infusions during surgery to improve pain management after open rhinoplasty. By targeting NMDA receptors in the nervous system, the study aims to reduce postoperative pain and decrease the need for opioids. The approach is based on the premise that the two substances can work synergistically to enhance analgesia. Patients undergoing this procedure will be monitored for pain levels and opioid consumption post-surgery.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 65 scheduled for open rhinoplasty under general anesthesia with ASA physical status I-II.
Not a fit: Patients with a history of drug addiction, significant cardiovascular or respiratory diseases, or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved pain management and higher patient satisfaction after rhinoplasty.
How similar studies have performed: Previous studies have shown that magnesium sulfate can effectively reduce opioid consumption, suggesting potential success for this combined approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 18 to 65 years. * Both sexes. * American Society of Anesthesiologists (ASA) physical status I - II. * Scheduled for rhinoplasty under general anesthesia. Exclusion Criteria: * Receiving analgesic or any medications since 48 hours before the surgery. * Drug addiction. * Cardiovascular disease. * Respiratory disease, renal, liver, metabolic and neurological disease. * Pregnancy or breast feeding. * Asthma.
Where this trial is running
Cairo
- Ain Shams University — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Sarah A Afifi, MD
- Email: Sarah606060@gmail.com
- Phone: 0501035864
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.