Low-Load Blood Flow Restriction Training for Colorectal Cancer Survivors with Sarcopenia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study investigates a low-load resistance program paired with blood flow restriction, compared with low-load resistance training without blood flow restriction, to see if it improves muscle strength, functional performance, and cancer-related fatigue in colorectal cancer survivors with probable sarcopenia. Eligible participants are adults aged 40–59 with colorectal cancer, probable sarcopenia, and medical clearance for supervised exercise. Outcomes include measures of strength, functional tests, and fatigue levels, with safety monitoring for cardiovascular and thromboembolic risks. The trial targets populations who may not tolerate high-load training due to cancer and prior treatments. The design is grounded in prior evidence suggesting potential benefits of low-load, blood flow-restricted exercise but seeks colorectal cancer-specific randomized data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Colorectal cancer with probable sarcopenia.
2. Age 40-59 years.
3. Low muscle strength defined by EWGSOP2 criteria using the five-times sit-to-stand test (\>15 seconds without upper limb support).
4. Current chemotherapy/radiotherapy or postoperative status with confirmed medical stability.
5. Medical clearance for supervised exercise.
6. Ability to follow instructions and complete assessments.

Exclusion Criteria:

1. Any contraindication to resistance or blood flow restriction training.
2. Uncontrolled cardiovascular disease or hypertension.
3. Recent thromboembolic events.
4. Severe peripheral vascular disease.
5. Uncontrolled treatment-related complications, such as severe anemia or infection.
6. Metastatic bone disease in the lower limbs.
7. Neurological or musculoskeletal disorders limiting safe participation.

Where it's running

• Private Clinics
  Cairo, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.