MASLD development in breast and colorectal cancer survivors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational cohort conducted at the University of Bern enrolling adults who were diagnosed with breast or colorectal cancer 5–10 years earlier and have had no recurrence. Participants will undergo non-invasive liver screening including imaging (with an MRI sub-study for eligible patients) and clinical/metabolic data collection to measure liver fat and stiffness. People with known chronic liver disease or pregnancy are excluded, and MRI-ineligible participants can be excluded from the MRI sub-study. The study aims to estimate the prevalence and severity of MASLD and identify metabolic or treatment-related factors linked to fibrosis in this survivor population.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Signed Informed consent form
* Age ≥ 18 years
* Diagnosis of BC or CRC at least 5 years but no more than 10 years before enrollment, and no recurrence or new cancer diagnoses during this time period (except for superficial non-melanoma skin cancer or superficial bladder cancer or cancer in-situ). Patients who received/are still receiving adjuvant therapy may be included. Time period is calculated from date of first histological diagnosis of cancer.

Exclusion criteria:

* Known or suspected chronic hepatic disease
* Pregnancy, or suspected pregnancy (as liver stiffness and fat content are often elevated but reverse after childbirth)
* For the MRI sub-study: Contraindication to MRI, including: claustrophobia and presence of metal implants or devices or foreign metal objects in/on the body, such as pacemakers, defibrillators, prosthetic cardiac valves, cochlear implants, metal clips e.g., vascular clips, spinal cord stimulators or deep brain stimulators, shrapnel or bullet fragments, metal in the eyes, orthopedic hardware and piercings that cannot be easily removed.

Where it's running

• Department of Clinical Research, University of Bern
  Bern, Switzerland Recruiting

Study contacts

• Principal investigator: Eva Segelov, Prof. — Department of Clinical Research, University of Bern
• Study coordinator: Study coordinator
• Email: evaluate.dcr@unibe.ch
• Phone: +41 79 804 04 05

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.