Low-Dose CT Lung Cancer Screening in Kuwait: Feasibility and Uptake

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, interventional feasibility study evaluates uptake and barriers to implementing low-dose CT screening for lung cancer in Kuwait. Eligible participants are adults aged 50-80 with at least 20 pack-years of smoking history, accounting for all tobacco products including shisha. Participants receive a baseline LDCT scan and may undergo two additional annual scans, with screening performed at the Chest Diseases Hospital and recruitment through MOH clinics. The primary goal is to establish a framework for a national screening program, while the co-primary analyses consider the baseline uptake and retention through 12 months. An extension cohort may enroll after the initial cohort closes, contributing to scan-based analyses but not to co-primary outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 50 to 80 years
* Smoking history of at least 20 pack-years, totalled across all smoked tobacco products (cigarettes, shisha/waterpipe, cigars, pipe and roll-your-own tobacco) using pre-specified equivalency conventions (1 shisha head-year = 1 pack-year; 1 cigar = 4 cigarettes; 1 pipe bowl = 2.5 cigarettes; roll-your-own tobacco 1 g = 1 cigarette). Electronic cigarettes, heated tobacco and smokeless products do not count. Current and former smokers are eligible regardless of time since quitting.
* Able to provide informed consent

Exclusion Criteria:

* Previous diagnosis of lung cancer or any other cancer
* Currently under surveillance for pulmonary nodules
* A major comorbidity under active management (for example end-stage heart, lung or liver disease); people whose condition is under routine follow-up, such as COPD on inhaled treatment, bronchiectasis or interstitial lung disease, remain eligible
* Unable to lie flat with arms raised above the head for CT scanning
* Symptoms suggestive of lung cancer (persistent or worsening cough, haemoptysis, or unexplained weight loss of more than 15 lb (about 7 kg) in the past 3-12 months); symptomatic people are referred the same day on the normal diagnostic pathway
* Chest CT for any reason in the past 12 months
* Non-Kuwaiti residents who have lived in Kuwait for less than 2 years

Where it's running

• Lung Cancer Screening Clinic, Chest Diseases Hospital
  Kuwait City, Kuwait Recruiting

Study contacts

• Principal investigator: Sulaiman Khadadah, MD — Chest Diseases Hospital, Ministry of Health, Kuwait
• Study coordinator: Sulaiman Khadadah, MD
• Email: khadadas@tcd.ie
• Phone: +96555966111

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.