Longitudinal study of intracranial atherosclerosis using advanced imaging techniques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the morphological changes and remodeling of intracranial atherosclerosis (ICAD) using 3D-rotational angiography (3DRA). By employing this advanced imaging technique, which offers superior spatial resolution, the study seeks to analyze the geometric parameters and luminal narrowing associated with ischemic strokes. The research will be conducted under strict control of cardiovascular risk factors, with assessments performed by a neuro-radiologist and a stroke neurologist who are blinded to the time sequence of imaging. This approach allows for a detailed understanding of stroke mechanisms and the evolution of ICAD over time.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patient is 30 to 85 years of age, inclusive.
2. Patients who have an acute infarct in diffusion-weighted MRI compatible with artery-to-artery thrombo-embolism and a relevant intracranial atherosclerotic stenosis ≥60%.
3. Patient who has no contra-indication for the proposed imaging tests.
4. Patient understands the purpose and requirements of the study, and has provided an informed consent.

Exclusion Criteria:

Patient with any of the following conditions would be excluded:

1. Stroke etiology uncertain or unrelated to intracranial atherosclerosis, such as cardioembolism, Moyamoya disease, small vessel disease or primary angiitis of CNS.
2. A tandem stenosis \>50% at extra-cranial internal carotid artery.
3. Bleeding propensity: active peptic ulcer disease, major systemic hemorrhage within 30 days, thrombocytopenia (platelets \<100 x 109/L), coagulopathy (INR \>1.5).
4. A medical condition that would not allow the patient to adhere to the protocol or complete the study.

Where it's running

• Chinese University of Hong Kong
  Hong Kong, Hong Kong Recruiting

Study contacts

• Principal investigator: Thomas Wai Hong LEUNG, FRCP — Chinese University of Hong Kong
• Study coordinator: Thomas Wai Hong LEUNG, FRCP
• Email: drtleung@cuhk.edu.hk
• Phone: 852-35053593

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.