Long-term follow-up for patients with migraine or medication-overuse headache after MRI scans

A Longitudinal Follow-up Study of the Patients With Medication-overuse Headache or Migraine That Completed Baseline MRI

Chinese PLA General Hospital · NCT05528081

This study is trying to see how migraine and medication-overuse headache patients feel over time after having MRI scans, focusing on their headaches, mental health, sleep, and daily life.

Quick facts

Study typeObservational
Enrollment122 (estimated)
Ages18 Years to 65 Years
SexAll
SponsorChinese PLA General Hospital (other)
Locations1 site (Beijing, Beijing)
Trial IDNCT05528081 on ClinicalTrials.gov

What this trial studies

This observational study involves phone interviews with patients diagnosed with migraine or medication-overuse headache who have completed baseline MRI scans. Participants will be assessed at 3, 12, and 24 months post-MRI to evaluate headache features, mental health, sleep quality, and functional disability. The goal is to identify brain signatures that may predict treatment outcomes and long-term effects of these conditions. The study is conducted by headache specialists at a dedicated headache center.

Who should consider this trial

Good fit: Ideal candidates are individuals diagnosed with migraine or medication-overuse headache who have completed baseline MRI scans and are willing to participate in follow-up phone interviews.

Not a fit: Patients who refuse or are unable to complete the phone interview will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding and management of migraine and medication-overuse headache.

How similar studies have performed: While similar studies have explored MRI findings in migraine, this specific longitudinal approach focusing on functional and structural brain signatures is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Participants who are diagnosed with migraine or MOH at baseline visit, signed the consent form, and completed MRI scans.
* Participants who are willing to take the phone interview during follow-up.

Exclusion Criteria:

* Refuse or unable to complete the phone interview procedure during follow-up.

Where this trial is running

Beijing, Beijing

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Migraine Disorders, Medication-overuse Headache, Migraine, MRI

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.