Long-term Aseptic Revision & Advanced Hip Arthroplasty Database (patient registry)
Official title: Long-term Follow-up of Patients Undergoing Aseptic Revision Hip Arthroplasty or Complex Primary Hip Arthroplasty Treated at University Hospitals Leuven
Run by Universitaire Ziekenhuizen KU Leuven · NCT07481448 · Data updated 2026-11-12
A prospective database is being collected to track complex hip replacements and revisions to see which implants and approaches work best for younger patients and complicated cases.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Locations | 1 site (Leuven, Vlaams-Brabant) |
| Status | Recruiting |
| Started | July 2026 |
| Main results expected | March 2037 |
| Study ends | March 2037 |
| Registry record updated | July 13, 2026 |
| Trial ID | NCT07481448 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients undergoing hip replacement for complex indications (e.g., dysplasia, deformity, prior surgery, infection, metabolic disorders) including those 25 years or younger.
✕Probably not a fit
Patients without complex or high-risk hip indications or those unwilling/unable to provide consent may experience no direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational data-collection effort at KU Leuven to document long-term outcomes of hip arthroplasty, including revisions, in patients with complex indications. The study collects prospective data to identify patterns in implant selection, surgical technique, and outcomes across diverse, high-risk cases. It emphasizes quality assurance through systematic audits, such as confirming complete infection workups before revision surgery. The population includes younger patients with congenital or prior conditions and older patients with comorbidities who require complex revisions. Randomized trials are not feasible due to heterogeneity, so the registry aims to inform practice through real-world evidence.
Why it matters
Potential benefit: If successful, the database could improve implant choices and clinical pathways for complex hip arthroplasty and revision cases, leading to better patient outcomes.
How similar studies have gone: Prior observational registries and multi-center databases have yielded actionable insights in complex hip arthroplasty, though with varying completeness and heterogeneity.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria:
* Patients undergoing a hip replacement for the following indications:
1. THA with hardware removal
2. THA for hip dysplasia
3. THA with femoral deformity or prior corrective surgery
4. THA after LCPD, SCFE or septic arthritis
5. THA in metabolic disease
6. THA in hyperlaxity (e.g. Ehlers-Danlos syndrome, Down syndrome)
7. THA with complex bony anatomy
8. THA in patients aged 25 years or younger
9. Other indications for which the treating surgeon expects increased surgical difficulty or increased risk of postoperative complications
Exclusion Criteria:
* Patients unable to provide written informed consent
* Patients who prefer treatment outside of University Hospitals Leuven
* Patients with proven PJI according to the 2021 EBJIS criteria
* Patients undergoing standard, non-complex, hip replacement as judged by the treating physician.
Where it's running
-
Universitaire Ziekenhuizen KU Leuven
Leuven, Vlaams-Brabant, Belgium Recruiting
Study contacts
- Principal investigator: Stijn Ghijselings, Dr. — UZ Leuven
- Study coordinator: Stijn Ghijselings, Dr.
- Email: stijn.ghijselings@uzleuven.be
- Phone: +32 16 33 88 72
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.