Liver transplantation for patients with colorectal cancer liver metastasis
Effectiveness of Liver Transplantation for Unresectable Colorectal Liver Metastasis; Pilot Study
This study is testing if living donor liver transplants can help people with colorectal cancer that has spread to the liver live longer and have better outcomes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 19 Years and up |
| Sex | All |
| Sponsor | Seoul National University Hospital Academic / other |
| Drugs / interventions | chemotherapy, immunotherapy |
| Locations | 1 site (Seoul) |
| Trial ID | NCT04874259 on ClinicalTrials.gov |
What this trial studies
This study evaluates the efficacy of living donor liver transplantation as a treatment option for patients with unresectable liver metastasis from colorectal cancer. It aims to determine if liver transplantation can improve survival rates in this patient population, which traditionally has a poor prognosis. Participants will undergo a thorough multidisciplinary assessment to confirm their eligibility for transplantation, and must have a willing, healthy living donor. The study is motivated by recent advancements in treatment that have shown improved outcomes for similar cases.
Who should consider this trial
Good fit: Ideal candidates are patients with isolated liver metastasis from colorectal cancer who have not received other treatments and have a willing living donor.
Not a fit: Patients with active disease outside the liver, those who have received prior treatments, or those with certain health conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve survival rates for patients with liver metastasis from colorectal cancer.
How similar studies have performed: Other studies have shown promising results for liver transplantation in similar contexts, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Proven colorectal cancer liver metastases without no other treatment (such as immunotherapy, chemotherapy, surgical resection, and radiofrequency ablation) * Metastasis isolated to liver * Patients selected as a liver transplant recipient at a multidisciplinary meeting * Paitents with a willing, healthy living donor * Willing and able to provide written informed consent Exclusion Criteria: * Pregnant women * Known history of human immunodeficiency virus (HIV) infection * Patients with active peptic ulcer within 2 weeks of transplantation * Persistent colorectal cancer after colon resection * Hemodynamically unstable prior to liver transplantation * Progression of LM at any timepoint prior to transplant surgery (assessed in a multidisciplinary meeting)
Where this trial is running
Seoul
- Seoul National University Hospital — Seoul, South Korea (Recruiting)
Study contacts
- Study coordinator: YoungRok Choi, MD
- Email: choiyoungrok@gmail.com
- Phone: 82-2072-0069
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.