Lipid and mitochondrial clues in aortic aneurysm with bicuspid or tricuspid valves

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study comparing molecular patterns in blood-derived myeloid cells and discarded ascending aortic tissue from patients undergoing surgical repair for ascending aortic aneurysm. The researchers will analyze inflammatory, metabolic, and transcriptomic signatures to identify differences related to valve morphology (bicuspid vs. tricuspid). By collecting additional blood samples and tissue, the study aims to reveal potential biomarkers and targets for therapy related to aneurysm progression. Eligibility focuses on adults planning surgery and confirmed valve architecture, with several exclusions to ensure safety and data quality. No interventional treatments are tested in this design; findings would inform future research and clinical understanding.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals who have given their consent
* Patients with an ascending aortic aneurysm for which surgical replacement is indicated
* Age \> 18 years
* Scheduled surgery
* Preoperative ultrasound confirmation of the heart valve architecture (bicuspid or tricuspid valve)

Exclusion Criteria:

* A person subject to a legal protective measure (guardianship, conservatorship)
* A person subject to a judicial safeguard measure - A pregnant woman, a woman in labor, or a breastfeeding woman
* Adults who are legally incapacitated or unable to give consent
* Emergency surgical procedures
* Patients with uncontrolled inflammatory or autoimmune conditions
* Patients with a history of recent acute infection (within the last 3 months or still undergoing treatment)
* Patients with a condition requiring immunosuppressants - Patients with a confirmed or suspected genetic aneurysm (Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome, etc.)
* Patients with a history of cardiac surgery

Where it's running

• Chu Dijon Bourgogne
  Dijon, France Recruiting

Study contacts

• Study coordinator: Comlan BLITTI
• Email: comlanmawuko.blitti@chu-dijon.fr
• Phone: 03.80.29.33.52

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Comparing self-expandable and balloon-expandable valves for aortic dilation treatment

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.