Lingzhi (CP003) for chronic fatigue syndrome and post-COVID fatigue

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, controlled study compares CP003 Lingzhi capsules to a waitlist control in adults with chronic fatigue syndrome or post-COVID fatigue. Participants take five capsules daily for six weeks and undergo two blood tests, plus fatigue and quality-of-life questionnaires. The study aims to determine if CP003 reduces fatigue symptoms and how it affects safety, immune markers, and inflammation. Results will inform whether CP003 could be a beneficial, safe option for these fatigue conditions. The lead institution is The University of Hong Kong, with collaboration from the Innovation and Technology Commission.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Meet the Fukuda diagnostic definition of CFS/ME or have persisting fatigue after the infection of SARS-CoV-2
* Are able to complete a 6-week course of intervention;
* Able to complete the online validated fatigue surveys.

Exclusion Criteria:

* Have participated in any type of complements or herbal medicine within the past six months;
* Have serious medical conditions that might limit their participation in this intervention;
* Diagnosed with acute inflammation;
* Are pregnant or are planning a pregnancy in the next 3 months.

Where it's running

• Specialist Clinical Centre for Teaching and Research, School of Chinese Medicine, The University of Hong Kong
  Hong Kong, Hong Kong Recruiting

Study contacts

• Study coordinator: Tung Leong Fong
• Email: tlfong@hku.hk
• Phone: +852 5660 4020

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Hydrogen water for ME/CFS: a 16-week comparison to placebo

  This 16-week pilot study tests whether hydrogen water helps reduce fatigue and improve physical function in adults with ME/CFS, compared with a placebo.

  Recruiting Stony Brook University · Stony Brook, New York · NCT07753122

• Photobiomodulation for Chronic Fatigue Syndrome: can light therapy help fatigue and quality of life?

  This study tests whether low-level laser therapy can reduce fatigue and improve quality of life in adults with chronic fatigue syndrome, compared with a sham treatment.

  Recruiting University of Lahore · Larkana, Sindh · NCT07546539

• Cognitive rehabilitation for ME/CFS brain fog

  Researchers are testing two cognitive rehabilitation approaches to see which helps adults with ME/CFS and brain fog better manage thinking and daily tasks.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT07523113

• Physical exercise and neuromodulation for fibromyalgia-related pain, sleep, and fatigue

  This project will try structured treadmill/balance training or gentle transcutaneous neuromodulation, each combined with usual physiotherapy, to see if they reduce pain, improve sleep, and lower fatigue in adults with fibromyalgia and chronic fatigue.

  Recruiting National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland · Warsaw, Masovian Voivodeship · NCT07242573

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.