Left Bundle Branch Area Pacing vs Right Ventricular Pacing for Atrial Fibrillation Risk in AV Block

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, randomized trial comparing two pacing strategies in adults with AV block. Participants are randomized to receive either left bundle branch area pacing or standard right ventricular pacing. The primary aim is to see if the pacing method influences the incidence of new-onset atrial fibrillation over follow-up. The study excludes patients with prior atrial fibrillation, certain heart conditions, or inability to complete two years of follow-up. Enrollment targets adults aged 18–85 who require ventricular pacing and meet specific AV block criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients aged 18-85;
* AV block patients with ventricular pacing indications and the expected rate of ventricular pacing(VP)\> 40%, including (a) third-degree AV block; (b) second degree AV block (type II); (c) intermittent advanced AV block with expected VP\>40%; (d) symptomatic first degree AV block and PR interval on ECG \> 300ms;
* Signed informed consent;

Exclusion Criteria:

* Baseline echocardiographic assessment of patients with impaired LV function (LVEF\<50%);
* Patients with the history of atrial fibrillation;
* Having difficulties in follow-up: Those who cannot accept 2-year follow-up on time due to physical condition or other reasons;
* Pacemaker replacement without new implanted ventricular electrodes;
* Surgery is required within 1 year due to severe structural heart disease;
* Patients with tricuspid mechanical valve replacement, or congenital heart disease (including transposition of the great arteries, or permanent left superior vena cava, etc);
* AV block resulting from: (a) Hypertrophic cardiomyopathy(HCM), (b) ventricular septal defect repair, and those who are unlikely to achieve successful LBBAP procedure.

Where it's running

• Chinese Academy of Medical Sciences & Peking Union Medical College, Peking Union Medical College Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Deyan Yang, PhD.
• Email: swallow_sums@163.com
• Phone: +86 (010)69155068

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.