Comparing two pacemaker pacing methods for AV block
Official title: The Pacing in Atrioventricular Block: a Comparative Evaluation of Central Haemodynamics, Cardiac Function, and Quality of Life
Run by University of Tartu · NCT07276490 · Data updated 2026-11-12
This trial tests whether conduction system (left bundle branch area) pacing or standard right ventricular pacing works better for people with atrioventricular block who need a permanent pacemaker.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 124 (estimated) |
| Sponsor | University of Tartu Academic / other |
| Locations | 2 sites (Tallinn, Harju and 1 other locations) |
| Status | Recruiting |
| Started | November 28, 2025 |
| Main results expected | June 1, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | March 9, 2026 |
| Trial ID | NCT07276490 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–80 with atrioventricular block who need a permanent pacemaker, have expected survival over one year, preserved left ventricular ejection fraction (≥45%), and are expected to have a ventricular pacing burden of ≥20% are ideal candidates.
✕Probably not a fit
Patients with reduced LVEF (<45%), expected ventricular pacing burden <20%, significant valvular or congenital heart disease, recent coronary revascularization, secondary hypertension, or pregnancy are unlikely to benefit from this specific comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a randomized, single-blind trial enrolling 124 adults with atrioventricular block who require permanent pacemaker implantation at two tertiary hospitals in Estonia. Participants are assigned to either conduction system pacing (left bundle branch area pacing) or standard right ventricular pacing and followed for 12 months. The primary outcome is central systolic arterial pressure, with secondary outcomes including measures of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life. The trial compares physiological central hemodynamics and cardiac function between the two pacing strategies.
Why it matters
Potential benefit: If successful, the results could guide choice of pacing method to better preserve central blood pressure, heart function, and quality of life after pacemaker implantation.
How similar studies have gone: Previous nonrandomized studies and limited randomized data suggest conduction system pacing can better preserve electrical synchrony and cardiac function than right ventricular pacing, but larger randomized evidence remains limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-80 years * Diagnosis of atrioventricular block * Expected survival \>1 year Exclusion Criteria: * Reduced left ventricular ejection fraction (EF \<45%) * Expected ventricular pacing burden \<20% * Inter-arm systolic blood pressure difference \>15 mmHg * Percutaneous coronary intervention or coronary artery bypass surgery within the last 30 days * Secondary hypertension * Orthostatic hypotension * Clinically significant valvular heart disease * Congenital heart disease * Pulse wave analysis or pulse wave velocity measurement cannot be reliably performed * Pregnancy or breastfeeding * Withdrawal of consent by the subject * Loss of contact during the study
Where it's running
-
North Estonia Medical Centre
Tallinn, Harju, Estonia Recruiting -
Tartu University Hospital
Tartu, Tartu, Estonia Recruiting
Study contacts
- Study coordinator: Silver Heinsar, MD, PhD
- Email: silver.heinsar@ut.ee
- Phone: +372 5333 1997
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Left bundle branch area pacing with Tendril STS or UltiPace leads
This study will try left bundle branch area pacing with the Tendril STS or UltiPace lead in adults who need pacemaker leads for bradycardia or related heart conditions to see if pacing and sensing are safe and work through six months after implant.
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Simplifying conduction system pacemaker implantation
This project will try new imaging and electrical mapping methods to make conduction system pacemakers easier to implant and interpret for adults who need ventricular pacing.
-
Comparing two pacing methods for heart failure patients
This study is testing whether a new pacing method called conduction system pacing can help heart failure patients just as much as the standard biventricular pacing to improve their heart function.
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Left Bundle Branch Area Pacing vs Right Ventricular Pacing for Atrial Fibrillation Risk in AV Block
This study tests whether left bundle branch area pacing can lower the chance of developing atrial fibrillation compared with traditional right ventricular pacing in adults with AV block.
-
Postoperative Atrial Pacing in Children After Heart Surgery
This study tests whether briefly raising a child’s heart rate after heart surgery improves blood flow and oxygen delivery by using temporary atrial pacing at 10 or 20 beats per minute above the child’s natural rate.
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Transjugular implantation of a leadless pacemaker (Aveir VR) for ventricular pacing
This study tests whether placing an Aveir VR leadless pacemaker through the neck vein can safely provide ventricular pacing in adults with bradycardia.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.