Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Laughter Yoga for People with Multiple Sclerosis

Official title: Evaluation of the Effects of Laughter Yoga on Pain Intensity, Stress, and Beta-endorphin Levels in Patients With Multiple Sclerosis

Run by Firat University · NCT07524231 · Data updated 2026-11-12

This will test whether laughter yoga can reduce pain and fatigue and boost natural pain-relief chemicals in adults with multiple sclerosis.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment72 (estimated)
SponsorFirat University
Academic / other
Locations1 site (Elâzığ)
StatusRecruiting
StartedMarch 10, 2026
Main results expectedJuly 10, 2026
Study endsAugust 10, 2026
Registry record updatedApril 13, 2026
Trial IDNCT07524231 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (age 18+) with multiple sclerosis who can communicate and participate in group sessions, are not in an acute relapse, and are not regularly enrolled in a similar complementary therapy program.

Probably not a fit

People with severe cognitive impairment, active psychiatric disorders, another serious chronic neurological disease, or those experiencing an acute MS relapse are unlikely to benefit or be eligible.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, controlled study will enroll adults with multiple sclerosis and randomly assign them to laughter yoga sessions or a comparison condition. The laughter yoga intervention combines breathing exercises, stretching, relaxation, and guided laughter activities delivered in group sessions. Primary outcomes include pain intensity and fatigue measured with validated scales, and a secondary outcome is change in blood beta-endorphin levels. Participants must be able to communicate and attend in-person sessions at Firat University in Elâzığ, Turkey, and those in an acute MS relapse or with severe cognitive or psychiatric problems are excluded.

Why it matters

Potential benefit: If successful, it could offer a low-cost, non-drug way to reduce pain and fatigue and improve well-being for people with MS.

How similar studies have gone: Small trials of laughter yoga and related mind-body therapies have shown mixed but sometimes promising effects on mood, pain, and fatigue, while robust evidence in MS remains limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* • Being over 18 years old

  * Being able to communicate adequately
  * Volunteering to participate in the research

Exclusion Criteria:

* Unwillingness to participate in the study

Having severe cognitive impairment that prevents understanding or participation in the intervention

Having a psychiatric disorder that may affect participation in the study

Experiencing an acute MS relapse during the study period

Having another serious neurological or chronic disease that may affect the study outcomes

Regular participation in another complementary therapy program similar to laughter yoga

Communication problems that prevent participation in the intervention sessions

Where it's running

  • Gül DURAL
    Elâzığ, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.