Clinical trial Recruiting at 1 site Interventional Ages 21 to 70

Lateral sinus lift with Xenograft alone vs L-PRF block plus Xenograft

Official title: Evaluation of Lateral Sinus Floor Elevation Using Xenograft Versus L-PRF Block Combined With Xenograft: A Randomized Controlled Clinical Trial

Run by Gulf Medical University · NCT07677007 · Data updated 2026-11-12

This study tests whether adding an L-PRF block to a Xenograft-assisted lateral sinus lift improves bone formation for dental implants in adults with limited upper jaw bone height.

More Sinus Floor Augmentation trials

Quick facts

Study typeInterventional
Ages21 Years to 70 Years
SexAll
Enrollment30 (estimated)
SponsorGulf Medical University
Academic / other
Locations1 site (Ajman, Ajman Emirate)
StatusRecruiting
StartedJanuary 1, 2026
Main results expectedJanuary 1, 2027
Study endsFebruary 1, 2027
Registry record updatedJune 30, 2026
Trial IDNCT07677007 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 21 years or older with residual bone height 2–5 mm in the posterior maxilla seeking implant rehabilitation.

Probably not a fit

Patients with poor healing potential, smoker >10 cigarettes/day, active sinus disease, or other exclusion criteria may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with insufficient bone height in the back of the upper jaw will undergo a lateral sinus floor elevation to enable implant placement. Participants are assigned to receive a lateral sinus lift with Xenograft alone or with an L-PRF block in addition to Xenograft. The trial will evaluate bone gain, graft stability, and implant success over follow-up visits. The study uses CBCT imaging and standard clinical assessments to compare outcomes between the two grafting approaches. This is an interventional study conducted at Gulf Medical University.

Why it matters

Potential benefit: If successful, patients may achieve greater bone formation and more reliable implant support with the L-PRF block addition.

How similar studies have gone: Prior literature supports xenografts for sinus augmentation, but the added benefit of L-PRF blocks requires confirmation in this context.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adults aged 21 years or older.
* Partially edentulous posterior maxilla requiring implant-supported rehabilitation.
* Residual bone height between 2 and 5 mm measured by CBCT.
* Good oral hygiene and compliance with maintenance visits.
* ASA I or II patients.
* Signed informed consent.

Exclusion Criteria:

* Uncontrolled systemic diseases.
* Smoking more than 10 cigarettes/day.
* Active sinus pathology or chronic sinusitis.
* Previous sinus augmentation surgery.
* Pregnancy or lactation.
* Bisphosphonate therapy.
* Immunocompromised patients.
* History of head and neck radiotherapy

Where it's running

  • Gulf Medical University
    Ajman, Ajman Emirate, United Arab Emirates
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.