Lateral sinus lift with Xenograft alone vs L-PRF block plus Xenograft
Official title: Evaluation of Lateral Sinus Floor Elevation Using Xenograft Versus L-PRF Block Combined With Xenograft: A Randomized Controlled Clinical Trial
Run by Gulf Medical University · NCT07677007 · Data updated 2026-11-12
This study tests whether adding an L-PRF block to a Xenograft-assisted lateral sinus lift improves bone formation for dental implants in adults with limited upper jaw bone height.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years to 70 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Gulf Medical University Academic / other |
| Locations | 1 site (Ajman, Ajman Emirate) |
| Status | Recruiting |
| Started | January 1, 2026 |
| Main results expected | January 1, 2027 |
| Study ends | February 1, 2027 |
| Registry record updated | June 30, 2026 |
| Trial ID | NCT07677007 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 21 years or older with residual bone height 2–5 mm in the posterior maxilla seeking implant rehabilitation.
✕Probably not a fit
Patients with poor healing potential, smoker >10 cigarettes/day, active sinus disease, or other exclusion criteria may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with insufficient bone height in the back of the upper jaw will undergo a lateral sinus floor elevation to enable implant placement. Participants are assigned to receive a lateral sinus lift with Xenograft alone or with an L-PRF block in addition to Xenograft. The trial will evaluate bone gain, graft stability, and implant success over follow-up visits. The study uses CBCT imaging and standard clinical assessments to compare outcomes between the two grafting approaches. This is an interventional study conducted at Gulf Medical University.
Why it matters
Potential benefit: If successful, patients may achieve greater bone formation and more reliable implant support with the L-PRF block addition.
How similar studies have gone: Prior literature supports xenografts for sinus augmentation, but the added benefit of L-PRF blocks requires confirmation in this context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 21 years or older. * Partially edentulous posterior maxilla requiring implant-supported rehabilitation. * Residual bone height between 2 and 5 mm measured by CBCT. * Good oral hygiene and compliance with maintenance visits. * ASA I or II patients. * Signed informed consent. Exclusion Criteria: * Uncontrolled systemic diseases. * Smoking more than 10 cigarettes/day. * Active sinus pathology or chronic sinusitis. * Previous sinus augmentation surgery. * Pregnancy or lactation. * Bisphosphonate therapy. * Immunocompromised patients. * History of head and neck radiotherapy
Where it's running
-
Gulf Medical University
Ajman, Ajman Emirate, United Arab Emirates Recruiting
Study contacts
- Study coordinator: Nesma Shemais, PhD
- Email: dr.nesma@gmu.ac.ae
- Phone: 0529961988
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Two bovine bone grafts in sinus lift with or without jaw marrow blood
This study tests whether adding a small amount of jawbone marrow blood to two bovine bone grafts helps create more new bone and height in sinus lift surgery for adults needing implants.
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This project will test whether digital planning and the position of implants after a sinus lift affect bone levels, gum health, crown shape, and patient satisfaction in adults with implants in the upper back jaw.
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This project tries to see if filling the socket after removing upper back teeth reduces the chance you'll need a sinus lift before getting a dental implant.
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This study is testing which of two types of bone grafts helps people keep their jawbone healthy after losing a front tooth before getting a dental implant.
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Maxillary sinus floor elevation using a buccal bony window technique
This study is testing a new surgical method for raising the maxillary sinus floor to see which technique works best for patients with different amounts of remaining bone.
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Enhanced hydrogel xenograft for open maxillary sinus augmentation
This study tests a hydrogel-enhanced xenograft material to lift the sinus floor during open augmentation and sees if it improves bone formation and tissue response compared with doing the augmentation without graft material.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.