Laparoscopy vs Open Surgery for Endometrial Cancer Staging in Low-Resource Settings

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional trial compares two surgical approaches for endometrial cancer staging: laparoscopic versus open (laparotomy). It focuses on early postoperative recovery, primarily time to ambulation, and also examines intraoperative metrics (operative time, blood loss, lymph node yield) and postoperative outcomes (complications, recovery quality, length of stay, same-day discharge). The study is set in a low-resource environment and aims to determine if minimally invasive surgery provides recovery and safety benefits without compromising oncologic adequacy. Eligibility includes confirmed endometrial carcinoma suitable for pelvic lymphadenectomy, good performance status, and informed consent. Exclusion criteria include advanced-stage disease, contraindications to laparoscopy, prior pelvic radiotherapy, or prior lymphadenectomy.

Why it matters

Who can join: the full rules

1. Inclusion criteria:

   * Histologically confirmed endometrial carcinoma, diagnosed by endometrial biopsy or dilatation and curettage.
   * patient candidate for pelvic lymphadenectomy according to risk stratification in endometrial cancer according to ESGO/ESTRO/ESP, 2021 (6).
   * Planned surgical staging including: total hysterectomy, bilateral salpingo-oophorectomy ± pelvic lymphadenectomy.
   * good performance status : ECOG 0, 1, 2
   * patients who provide informed written consent to participate in the study.
2. Exclusion criteria:

   * severe cardiopulmonary diseases (e.g unstable angina, severe COPD).
   * Absolute contraindication to laparoscopy.
   * stage Ⅲ and Ⅳ endometrial cancer.
   * patients who received previous pelvic radiotherapy.
   * patients who underwent prior lymphadenectomy.

Where it's running

• Assiut University, Assiut,
  Asyut, Egypt Recruiting

Study contacts

• Study coordinator: Alaa El-Din Mahmoud Ismail, professor
• Email: alaaismail@aun.edu.eg
• Phone: +201001106048

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.