Comparing two methods of ondansetron administration for pain relief after weight loss surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective randomized non-inferiority study aims to evaluate the analgesic and anti-emetic effects of intravenous ondansetron versus perineural ondansetron in patients undergoing laparoscopic sleeve gastrectomy. The study focuses on addressing postoperative pain and nausea, which are common complications following bariatric surgery. By utilizing a novel approach called paragastric autonomic neural blockade, the researchers will assess the effectiveness of these two methods in managing symptoms post-surgery. The goal is to determine if perineural administration provides similar or superior benefits compared to the traditional intravenous route.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients of either sex
* American Society Anesthesiologists physical (ASA) status II-III
* age between 18-65 years old
* Body mass index (BMI) \>35 kg/m2 with comorbidity or \> 40 kg/m2 -- undergoing laparoscopic sleeve gastrectomy with intraoperative surgeon performed laparoscopic paragastric autonomic neural blockade..

Exclusion Criteria:

* Allergy to experimental drugs.
* Known to have long QT, previous history of postoperative nausea and vomiting
* Abuse of alcohol, analgesia, or sedative antidepressant drugs
* Chronic pain disorders
* History of previous upper gastrointestinal system surgery, those with surgery-related complications during or after surgery.
* Liver or kidney failure
* Performance of concomitant procedures in addition to laparoscopic sleeve gastrectomy
* Anesthetic complications that may alter the postoperative management protocol.

Where it's running

• Tanta University Hospitals
  Tanta, Gharbia Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Osama M Rehab, MD
• Email: osamarehab@med.tanta.edu.eg
• Phone: 01095210806

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.