KLF4 Epigenetic Modulation in Colorectal Tissue
Official title: KLF4 Epigenetic Modulation During Polyps-adenoma Progression
Run by Azienda USL Reggio Emilia - IRCCS · NCT07901335 · Data updated 2026-11-12
Researchers will look at how the KLF4 gene’s methylation changes as colorectal tissue moves from polyps to more advanced lesions to see if this reflects or relates to gene activity.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 170 (estimated) |
| Sponsor | Azienda USL Reggio Emilia - IRCCS Government |
| Locations | 1 site (Reggio Emilia) |
| Status | Recruiting |
| Started | October 30, 2026 |
| Main results expected | July 2027 |
| Study ends | July 2028 |
| Registry record updated | November 10, 2026 |
| Trial ID | NCT07901335 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults undergoing routine colonoscopy at AUSL-IRCCS Reggio Emilia who consent to tissue use and do not have a concurrent colorectal carcinoma.
✕Probably not a fit
Patients with concurrent colorectal cancer or those not contributing tissue samples may not benefit directly.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study will measure quantitative KLF4 DNA methylation and KLF4 RNA expression in colorectal tissue obtained during routine colonoscopies at a single center in Reggio Emilia. The goal is to map methylation across different stages of colorectal lesion progression and to compare methylation with gene expression in matched samples. In addition, the study will explore various molecular methods to assess methylation at global and site-specific levels. Samples are FFPE tissues collected with informed consent and will not alter standard diagnostic procedures.
Why it matters
Potential benefit: If successful, the findings could improve understanding of how KLF4 regulation relates to colorectal lesion progression, potentially guiding future biomarker development.
How similar studies have gone: Previous work has explored KLF4 methylation in cancer, but this study applies quantitative and site-specific approaches to a progression spectrum, making findings relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing routine colonoscopy * \> 18 years of age * Diagnosed by S.C. Anatomia Patologica, AUSL-IRCCS Reggio Emilia Exclusion Criteria: * Concomitant diagnosis of colorectal carcinoma
Where it's running
-
Azienda USL IRCCS di Reggio Emilia
Reggio Emilia, Italy Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.